| Uptake and utilization of arachidonic acid in infective larvae of Angiostrongylus cantonensis. | |
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MedLine Citation:
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PMID: 21106133 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Infective larvae of Angiostrongylus cantonensis may take up and incorporate exogenous arachidonic acid into their lipid pool. By scintillation counting, uptake and incorporation were determined to be time dependent. Arachidonic acid was mainly incorporated into phospholipid (56.8%) and neutral lipid (22.4%) pools. In the neutral lipids, 64.0% was diglyceride and 36.0% triglyceride. Phosphatidylcholine was the predominant fatty acid in the phospholipid pool. In addition to the release of leukotriene B4, the parasite was found to generate radiolabelled CO2 after incubation with [U-14C]arachidonate. Moreover, enzymatic analysis of crude extracts revealed the presence of acyl-CoA dehydrogenase (short and long chain), thiolase, enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase. These findings suggest that infective larvae of A. cantonensis not only take up and incorporate exogenous arachidonic acid into their lipid pool, but may also utilize the fatty acid through a functional β-oxidation pathway. |
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Authors:
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P Tang; L-C Wang |
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Publication Detail:
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Type: Journal Article Date: 2010-11-25 |
Journal Detail:
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Title: Journal of helminthology Volume: 85 ISSN: 1475-2697 ISO Abbreviation: J. Helminthol. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985115R Medline TA: J Helminthol Country: England |
Other Details:
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Languages: eng Pagination: 395-400 Citation Subset: IM |
Affiliation:
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Department of Parasitology, College of Medicine, Chang Gung University, Tao-Yuan 33332, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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