Document Detail

Uptake of meningococcal vaccine in Arizona schoolchildren after implementation of school-entry immunization requirements.
MedLine Citation:
PMID:  23277658     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Meningitis and bacteremia due to Neisseria meningitidis are rare but potentially deadly diseases that can be prevented with immunization. Beginning in 2008, Arizona school immunization requirements were amended to include immunization of children aged 11 years or older with meningococcal vaccine before entering the sixth grade. We describe patterns in meningococcal vaccine uptake surrounding these school-entry requirement changes in Arizona.
METHODS: We used immunization records from the Arizona State Immunization Information System (ASIIS) to compare immunization rates in 11- and 12-year-olds. We used principal component analysis and hierarchical cluster analysis to identify and analyze demographic variables reported by the 2010 U.S. Census.
RESULTS: Adolescent meningococcal immunization rates in Arizona increased after implementation of statewide school-entry immunization requirements. The increase in meningococcal vaccination rates among 11- and 12-year-olds from 2007 to 2008 was statistically significant (p<0.0001). All demographic groups had significantly higher odds of on-schedule vaccination after the school-entry requirement change (odds ratio range = 5.57 to 12.81, p<0.0001). County demographic factors that were associated with lower odds of on-schedule vaccination included higher poverty, more children younger than 18 years of age, fewer high school graduates, and a higher proportion of Native Americans.
CONCLUSIONS: This analysis suggests that implementation of school immunization requirements resulted in increased meningococcal vaccination rates in Arizona, with degree of response varying by demographic profile. ASIIS was useful for assessing changes in immunization rates over time. Further study is required to identify methods to control for population overestimates in registry data.
Jennifer E Simpson; Rebecca A Hills; Deborah Allwes; Lisa Rasmussen
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  Public health reports (Washington, D.C. : 1974)     Volume:  128     ISSN:  1468-2877     ISO Abbreviation:  Public Health Rep     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-03-07     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  9716844     Medline TA:  Public Health Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-45     Citation Subset:  AIM; IM    
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MeSH Terms
Cluster Analysis
Immunization / legislation & jurisprudence*
Indians, North American
Logistic Models
Meningitis, Meningococcal / prevention & control*
Meningococcal Vaccines / administration & dosage*
Neisseria meningitidis / immunology
Odds Ratio
Socioeconomic Factors
Vaccination / statistics & numerical data*
Reg. No./Substance:
0/Meningococcal Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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