| Uptake of mangafodipir trisodium in liver metastases from endocrine tumors. | |
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MedLine Citation:
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PMID: 9626886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the study was to investigate retrospectively whether mangafodipir trisodium (MnDPDP) can enhance the liver metastases from endocrine tumors. Thirteen patients with endocrine tumors and liver metastases underwent T1-weighted spin-echo (SE) and turbo gradient-echo (GRE) MRI conducted before and 20 to 60 minutes after i.v. infusion of MnDPDP. Additional 24-hour-delay scans were performed in 8 of 13 patients. MR signal intensity (SI) was measured in liver parenchyma and metastases, which was then related to that of paraspinal muscle. A total of 30 lesions on precontrast and postcontrast images and 18 lesions on 24-hour-delay images were measured. An enhancement by 49% in SE and 40% in GRE images (P = .0001) was observed in tumor tissues after MnDPDP infusion. In 24-hour-delay images, the SI of the lesions remained relatively high, but in liver parenchyma, it decreased significantly, and the tumor-liver tissue contrast was reduced. |
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Authors:
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C Wang; H Ahlström; B Eriksson; M Lönnemark; S McGill; A Hemmingsson |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase II; Clinical Trial, Phase III; Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 8 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 1998 May-Jun |
Date Detail:
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Created Date: 1998-08-27 Completed Date: 1998-08-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 682-6 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, Uppsala University Hospital, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoid Tumor / blood, diagnosis* Carcinoma, Islet Cell / blood, diagnosis* Contrast Media* Edetic Acid / analogs & derivatives*, diagnostic use, pharmacokinetics Female Gastrinoma / blood, diagnosis* Glucagonoma / blood, diagnosis* Humans Image Enhancement Liver / pathology Liver Neoplasms / blood, diagnosis, secondary* Male Metabolic Clearance Rate / physiology Middle Aged Pancreatic Neoplasms / blood, diagnosis* Pyridoxal Phosphate / analogs & derivatives*, diagnostic use, pharmacokinetics Retrospective Studies Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 119797-12-5/N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid; 54-47-7/Pyridoxal Phosphate; 60-00-4/Edetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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