| Uptake of lipids into rabbit jejunum and colon following ileal resection. Effect of variations in dietary content of carbohydrate. | |
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MedLine Citation:
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PMID: 3943447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was undertaken to determine the effect of variations in the dietary content of carbohydrate (sucrose) and intestinal resection on the passive jejunal and colonic uptake of short-, medium-, and long-chain length fatty acids, cholesterol, and decanol. A previously validated in vitro technique was used, and studies were performed in sham-operated control animals and in rabbits submitted to the surgical removal of the distal half of the small intestine. After six weeks feeding of a high- or low-carbohydrate diet, the uptake of lipids was altered, but the direction and extent of changes was different among jejunum, ileum, and colon in control animals, and between the jejunum or colon of control vs resected animals. The intestinal membrane is likely heterogeneous with respect to passive permeability pathways since dietary manipulation of sucrose had a different effect on the uptake of each lipid probe. The finding of lower jejunal and colonic cholesterol uptake in animals fed a high- as compared with a low-carbohydrate diet reflects the importance of dietary effects on intestinal permeation. Studies must now be performed to establish the mechanisms responsible for these diet-related changes in intestinal permeability. |
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Authors:
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A B Thomson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 31 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1986 Feb |
Date Detail:
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Created Date: 1986-03-14 Completed Date: 1986-03-14 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 193-201 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Membrane Permeability Cholesterol / metabolism Colon / metabolism* Dietary Carbohydrates / administration & dosage* Diffusion Fatty Acids / metabolism Fatty Alcohols / metabolism Ileum / physiology, surgery* Intestinal Absorption Intestinal Mucosa / metabolism Jejunum / metabolism* Lipid Metabolism* Male Rabbits Sucrose / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Fatty Acids; 0/Fatty Alcohols; 112-30-1/n-decyl alcohol; 57-50-1/Sucrose; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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