| Uptake of first two doses of human papillomavirus vaccine by adolescent schoolgirls in Manchester: prospective cohort study. | |
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MedLine Citation:
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PMID: 18436917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the feasibility and acceptability of delivering a human papillomavirus (HPV) vaccine to adolescent girls. DESIGN: Prospective cohort study. SETTING: 36 secondary schools in two primary care trusts in Greater Manchester, United Kingdom. PARTICIPANTS: 2817 schoolgirls in year 8 (12 and 13 year olds). INTERVENTION: Delivery of the bivalent vaccine at 0, 1, and 6 months over one school year. MAIN OUTCOME MEASURES: Vaccine uptake for doses 1 and 2 of a three dose schedule. RESULTS: Vaccine uptake was 70.6% (1989/2817) for the first dose and 68.5% (1930/2817) for the second dose. Uptake was significantly lower in schools with a higher proportion of ethnic minority girls (P<0.001 for trend) or higher proportion of girls entitled to free school meals (P=0.029 for trend). The main reason for parents' refusal of vaccination was insufficient information about the vaccine and its long term safety. Maintaining the vaccine schedule was challenging as 16.3% (dose 1) and 23.6% (dose 2) of girls missed their vaccination day and had to be offered alternative appointments. No serious adverse events were reported. CONCLUSION: Delivery of the first two doses of HPV vaccine to adolescent schoolgirls is encouraging, but the success of the vaccination programme depends on high coverage for the third dose. |
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Authors:
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Loretta Brabin; Stephen A Roberts; Rebecca Stretch; David Baxter; Gloria Chambers; Henry Kitchener; Rosemary McCann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-24 |
Journal Detail:
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Title: BMJ (Clinical research ed.) Volume: 336 ISSN: 1756-1833 ISO Abbreviation: BMJ Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-09 Completed Date: 2008-05-28 Revised Date: 2012-03-06 |
Medline Journal Info:
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Nlm Unique ID: 8900488 Medline TA: BMJ Country: England |
Other Details:
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Languages: eng Pagination: 1056-8 Citation Subset: AIM; IM |
Affiliation:
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Academic Unit of Obstetrics and Gynaecology, St Mary's Hospital, University of Manchester, Manchester M13 OJH. loretta.brabin@manchester.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Cohort Studies Delivery of Health Care England Female Humans Papillomavirus Infections / prevention & control* Papillomavirus Vaccines / administration & dosage* Patient Acceptance of Health Care / statistics & numerical data* Prospective Studies School Health Services Vaccination / utilization |
| Chemical | |
Reg. No./Substance:
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0/Papillomavirus Vaccines |
| Comments/Corrections | |
Comment In:
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BMJ. 2008 May 24;336(7654):1146
[PMID:
18497380
]
BMJ. 2008 May 10;336(7652):1028-9 [PMID: 18436916 ] BMJ. 2008 May 24;336(7654):1146 [PMID: 18497381 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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