| Uptake and excretion of vecuronium bromide and pancuronium bromide in the isolated perfused rat liver. | |
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MedLine Citation:
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PMID: 2902816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using the isolated perfused rat liver preparation, the disappearance from the perfusate and the excretion in the bile of vecuronium bromide and pancuronium bromide and their metabolites were followed for 2 h after the addition of 1 mg of either drug to the perfusate. In addition, the rate of change of the hepatic content of these two compounds was calculated by serially subtracting the amount of the compound and the metabolites in the bile and in the perfusate from the dose of drug added to the perfusate. It was found that, whereas the concentration of pancuronium in the perfusate declined slowly and monoexponentially, vercuronium concentration in the perfusate declined rapidly in a biexponential manner. No metabolites of either drug were detected in the perfusate. Approximately 40% of the injected dose of vecuronium was excreted in the bile as unchanged vecuronium and another 30% as the 3-hydroxy metabolite. No other metabolites of vecuronium were found in the bile. In total only about 7% of pancuronium (unchanged) was collected in the bile by the end of the experiment. It is concluded that, in comparison to pancuronium, the rat liver takes up large amounts of vecuronium rapidly, half of which is eliminated as unchanged vecuronium and half as the 3-hydroxy derivative. A small amount of vecuronium or its 3-hydroxy metabolite is returned to the perfusate from the liver. Some possible mechanisms underlying these differences are discussed. |
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Authors:
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A F Bencini; W E Mol; A H Scaf; U W Kersten; K T Wolters; S Agoston; D K Meijer |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Anesthesiology Volume: 69 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1988-11-07 Completed Date: 1988-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 487-92 Citation Subset: AIM; IM |
Affiliation:
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Institute of Anesthesiology, University of Groningen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / metabolism* Liver / metabolism* Male Pancuronium / pharmacokinetics* Perfusion Rats Rats, Inbred Strains Vecuronium Bromide / pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Pancuronium; 50700-72-6/Vecuronium Bromide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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