Document Detail

Uptake of enflurane and isoflurane during spontaneous and controlled ventilation.
MedLine Citation:
PMID:  1534467     Owner:  NLM     Status:  MEDLINE    
The uptake of enflurane and of isoflurane were studied in forty patients during anaesthesia with nitrous oxide using either spontaneous or controlled ventilation. A Douglas bag method was used in combination with low fresh gas flows to a circle system and constant end-tidal anaesthetic concentration. The mean enflurane uptake rates were between 24 and 14 ml.70kg-1.min-1 between 10 and 60 minutes. Corresponding isoflurane uptake rates were between 15 and 8 ml. 70 kg-1.min-1. The initial uptake rates were lower than expected from "the square root of time concept". During spontaneous ventilation, the anaesthetic uptake rates were similar or even higher than corresponding rates during controlled ventilation in spite of lower minute ventilation volumes.
J P Bengtson; A Bengtsson; O Stengvist
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  20     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-06-29     Completed Date:  1992-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  191-5     Citation Subset:  IM    
Department of Anaesthesia and Intensive Care, Sahlgren Hospital, University of Göteborg, Sweden.
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MeSH Terms
Anesthesia, Inhalation* / instrumentation
Anesthesia, Intravenous
Carbon Dioxide / analysis
Enflurane / administration & dosage,  pharmacokinetics*
Equipment Design
Isoflurane / administration & dosage,  pharmacokinetics*
Lung / metabolism
Nitrous Oxide / administration & dosage,  analysis
Oxygen / administration & dosage,  analysis
Respiration, Artificial*
Thiopental / administration & dosage
Tidal Volume
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 124-38-9/Carbon Dioxide; 13838-16-9/Enflurane; 26675-46-7/Isoflurane; 76-75-5/Thiopental; 7782-44-7/Oxygen
Comment In:
Anaesth Intensive Care. 1992 Nov;20(4):543   [PMID:  1463208 ]

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