Document Detail

Uptake and elimination of chlorpyrifos and pentachlorophenol into the freshwater amphipod Gammarus pulex.
MedLine Citation:
PMID:  16944039     Owner:  NLM     Status:  MEDLINE    
Uptake and elimination rates were determined for chlorpyrifos (CPF) and pentachlorophenol (PCP) in the freshwater amphipod Gammarus pulex. Internal concentrations of the two pesticides were measured over a three-day exposure phase and a subsequent three-day elimination phase. Rate constants were obtained by fitting measured internal concentrations to a one-compartment single first-order model. The uptake rate constants were 747+/-61 [L kg-1 day-1] for CPF and 89+/-7 [L kg-1 day-1] for PCP. The elimination rate constants were 0.45+/-0.05 [day-1] for CPF and 1.76+/-0.14 [day-1] for PCP. The resulting bioconcentration factors at steady state were 1660 and 51 for CPF and PCP, respectively. The parameter estimation method and possible variability due to varying lipid content are briefly discussed.
Roman Ashauer; Alistair Boxall; Colin Brown
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Publication Detail:
Type:  Journal Article     Date:  2006-08-30
Journal Detail:
Title:  Archives of environmental contamination and toxicology     Volume:  51     ISSN:  0090-4341     ISO Abbreviation:  Arch. Environ. Contam. Toxicol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-16     Completed Date:  2006-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0357245     Medline TA:  Arch Environ Contam Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  542-8     Citation Subset:  IM    
Environment Department, University of York, York, YO10 5DD, United Kingdom.
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MeSH Terms
Amphipoda / metabolism*
Chlorpyrifos / pharmacokinetics*
Fresh Water
Insecticides / pharmacokinetics*
Pentachlorophenol / pharmacokinetics*
Quantitative Structure-Activity Relationship
Water Pollutants, Chemical / pharmacokinetics*
Reg. No./Substance:
0/Insecticides; 0/Water Pollutants, Chemical; 2921-88-2/Chlorpyrifos; 87-86-5/Pentachlorophenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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