| Uptake and effects of thiopental in isolated heart preparations of the rat in the presence of halothane. | |
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MedLine Citation:
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PMID: 8447839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The uptake of thiopental (CAS 76-75-5) (0.13-0.27 mmol.l-1) into tissue of rat hearts (Langendorff's preparation) was studied in the presence of halothane (CAS 151-67-7). Up to a thiopental concentration of 0.19 mmol.l-1 in the perfusion medium its concentration in heart tissue was significantly increased vs. control when halothane (0.8 vol%) simultaneously was present; using 0.13 mmol.l-1 thiopental and 0.8, 1.5 or 2.0 vol% halothane this increase amounted +12%, +29% and +43%, respectively. Frequency of spontaneously beating rat hearts decreased in the presence of increasing thiopental concentrations. 0.8 vol% halothane (without thiopental) did not influence heart rate; in the presence of thiopental it attenuated heart rate reduction. This attenuation was absent in hearts of rats pretreated with reserpine. 1.5 vol% halothane (itself also without influence on heart rate) increased the negative chronotropic action of thiopental. In isolated right and left atria of rat hearts frequency and contractility decreased concentration-dependently in the presence of thiopental; simultaneously present halothane additionally increased this negative chronotropic and negative inotropic effect of thiopental. |
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Authors:
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U Büch; J C Isenberg; J Baldauf; P Altmayer; H P Büch |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 43 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1993 Jan |
Date Detail:
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Created Date: 1993-04-08 Completed Date: 1993-04-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY |
Other Details:
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Languages: eng Pagination: 1-5 Citation Subset: IM |
Affiliation:
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Klinik für Anästhesiologie und Intensivmedizin, Universität des Saarlandes, Homburg/Saar, Fed. Rep. of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, Thin Layer Female Halothane / pharmacology* Heart / drug effects* Heart Rate / drug effects Male Myocardial Contraction / drug effects Myocardium / metabolism* Rats Rats, Wistar Reserpine / pharmacology Thiopental / pharmacokinetics*, pharmacology* |
| Chemical | |
Reg. No./Substance:
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151-67-7/Halothane; 50-55-5/Reserpine; 76-75-5/Thiopental |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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