Document Detail


Uptake and distribution of halothane in infants: in vivo measurements and computer simulations.
MedLine Citation:
PMID:  6829943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We measured uptake of halothane (the fraction of halothane in expired gas divided by the fraction of halothane in inspired gas, FE/FI) with a mass spectrometer over time in 7 infants less than 3 months of age. FE/FI for halothane in these infants increased more rapidly than has been described in adults by others. In addition, we developed a mathematical model for halothane uptake and distribution that incorporates age-dependent anatomic and physiologic parameters (alveolar ventilation, functional residual capacity, cardiac output, brain volume, etc). The model closely predicts FE/FI for halothane measured in the infants. At 5 min observed FE/FI was 0.67, at 15 min observed FE/FI was 0.80, while the predicted FE/FI values were 0.65 and 0.82, respectively. The model predicts that the myocardial and brain halothane concentrations will increase more rapidly in the infant than in the adult. Achievement of high myocardial halothane concentrations early in the anesthetic induction may cause the hypotension and bradycardia commonly seen in infants. Sensitivity of the infant myocardium to halothane would further exacerbate the effect of more rapid myocardial uptake.
Authors:
B W Brandom; R B Brandom; D R Cook
Related Documents :
19355873 - Circulating biochemical markers of brain damage in infants complicated by ischemia repe...
23326983 - The incidence of common orthopaedic problems in newborn at siriraj hospital.
3606233 - Gastric transposition for esophageal replacement in children.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  62     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-04-21     Completed Date:  1983-04-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  404-10     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Animals
Brain Chemistry
Computers*
Halothane / analysis,  metabolism*
Hemodynamics / drug effects
Humans
Infant
Kinetics
Myocardium / analysis
Rats
Chemical
Reg. No./Substance:
151-67-7/Halothane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs followi...
Next Document:  Cardiovascular effects of inhalation induction with isoflurane in infants.