Document Detail

Uptake and distribution of catechins in fetal organs following in utero exposure in rats.
MedLine Citation:
PMID:  16959805     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although catechins are known to be powerful antioxidants, no reports have shown their transport to fetal organs. We investigated the distribution of catechins in fetal rat organs after maternal exposure to green tea extract (GTE). METHODS: GTE (550 mg/kg) or water was fed orally to pregnant dams at 15.5 days of gestation, the dams were sacrificed and fetal organs were dissected 0, 0.5, 1, 2, 3, 5, and 8 h later. Catechins and catechin gallates were determined by high-performance liquid chromatography (HPLC) after solid-phase extraction. RESULTS: In the GTE-treated group, catechins were detected in most of the fetal organs studied, including the brain, eyes, heart, lungs, kidneys and liver but not in the control group. The first peak times (T(max)) were about 0.5-1 h. The maximum concentrations (C(max)) of catechins in the fetal eye were about 2-10 times higher than in the other organs, ranging from 249 pmol/g for epicatechin (EC) to 831 pmol/g for epigallocatechin gallate (EGCG). Catechin gallates were generally more readily taken up by fetal organs than catechins. EGCG had the highest level of uptake according to area under the curve (AUC) plots and the highest C(max) in all organs. CONCLUSIONS: Various fetal organs had low but significant levels of catechins after GTE intake by the dams, and organ levels were found to be related to catechin structure. EGCG could be a potential candidate for antioxidant supplementation of the fetus in utero.
K O Chu; C C Wang; C Y Chu; K W Choy; C P Pang; M S Rogers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-07
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  22     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  280-7     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, The Chinese Univerity of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong.
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MeSH Terms
Brain / embryology,  metabolism
Camellia sinensis / chemistry
Catechin / analogs & derivatives,  blood,  metabolism*
Eye / embryology,  metabolism
Fetal Heart / metabolism
Fetus / metabolism*
Kidney / embryology,  metabolism
Liver / embryology,  metabolism
Lung / embryology,  metabolism
Maternal-Fetal Exchange*
Plant Extracts / metabolism
Tissue Distribution
Reg. No./Substance:
0/Plant Extracts; 154-23-4/Catechin; 989-51-5/epigallocatechin gallate

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