| Uptake of dihomo-gamma-linolenic acid by murine macrophages increases series-1 prostaglandin release following lipopolysaccharide treatment. | |
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MedLine Citation:
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PMID: 20347284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Administration of dihomo-gamma-linolenic acid is useful for atopic dermatitis and atherosclerosis in mice; however, the metabolites of dihomo-gamma-linolenic acid have been little studied. We employed a method which enabled simultaneous analysis of nine prostaglandins using liquid chromatography-tandem mass spectrometry, and determined the concentrations of prostaglandins in the supernatants of cultures of mouse peritoneal macrophages stimulated with lipopolysaccharide after pre-incubation with dihomo-gamma-linolenic acid, arachidonic acid, or eicosapentaenoic acid. Accumulated prostaglandin concentrations from mouse macrophages with dihomo-gamma-linolenic acid uptake increased in a dihomo-gamma-linolenic acid concentration-dependent fashion. These increases were mainly due to prostaglandin D(1) and prostaglandin E(1). The order of accumulated prostaglandin concentrations was dihomo-gamma-linolenic acid>arachidonic acid>eicosapentaenoic acid in supernatants with the same concentration of polyunsaturated fatty acid. Since mouse macrophages can clearly produce series-1 prostaglandins, they must be formed in vivo. These findings suggest that the effects of dihomo-gamma-linolenic acid on diseases may be due to series-1 prostaglandins. |
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Authors:
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Saki Kakutani; Hiroshi Kawashima; Takao Tanaka; Akiko Shiraishi-Tateishi; Yoshinobu Kiso |
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Publication Detail:
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Type: Journal Article Date: 2010-03-26 |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 83 ISSN: 1532-2823 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 23-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Institute for Health Care Science, Suntory Wellness Ltd., Shimamoto, Osaka 618-8503, Japan. Saki_Kakutani@suntory.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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8,11,14-Eicosatrienoic Acid
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pharmacology* Alprostadil / secretion* Animals Arachidonic Acid / pharmacology Dermatitis, Atopic / drug therapy, metabolism Dose-Response Relationship, Drug Eicosanoic Acids / pharmacology Humans Lipopolysaccharides / pharmacology* Macrophages, Peritoneal / cytology, secretion* Mice Mice, Inbred BALB C Prostaglandins D / secretion* |
| Chemical | |
Reg. No./Substance:
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0/Eicosanoic Acids; 0/Lipopolysaccharides; 0/Prostaglandins D; 506-32-1/Arachidonic Acid; 7324-41-6/8,11,14-Eicosatrienoic Acid; 745-65-3/Alprostadil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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