| Uptake of amino acids and nucleic acid precursors by regenerating rat liver. | |
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MedLine Citation:
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PMID: 4119044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. At 0.5-1.0h after partial hepatectomy the intracellular acid-soluble fraction of rat liver took up twice as much radioactivity from [(3)H]orotic acid, [(3)H]uridine and [(3)H]thymidine as did similar fractions from sham-operated animals. This increase in penetration was not prevented by adrenalectomy or actinomycin, both of which decreased precursor uptake into nuclear RNA at this time. The increase in entry was still shown by thymidine at 22h after operation, at the height of the S period. Adenine penetration was not increased 1h after partial hepatectomy. 2. Plasma concentrations of ornithine and possibly methionine, tyrosine and lysine were raised 1.5h after partial hepatectomy. [(3)H]Lysine entry into regenerating liver at this time was increased by 60%; [(3)H]valine uptake was unaffected. Intracellular amounts of tyrosine, phenylalanine and ornithine in the liver were also increased. 3. The relation of these events to the start of liver regeneration is discussed. |
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Authors:
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M G Ord; L A Stocken |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Biochemical journal Volume: 129 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1972 Aug |
Date Detail:
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Created Date: 1973-03-08 Completed Date: 1973-03-08 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 175-81 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenine
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metabolism Adrenalectomy Amino Acids / metabolism* Animals Dactinomycin Hepatectomy Liver / metabolism Liver Regeneration* Lysine / metabolism Male Ornithine / metabolism Orotic Acid / metabolism* Phenylalanine / metabolism RNA Rats Thymidine / metabolism* Tritium Tyrosine / metabolism Uridine / metabolism* Valine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 10028-17-8/Tritium; 50-76-0/Dactinomycin; 50-89-5/Thymidine; 55520-40-6/Tyrosine; 56-87-1/Lysine; 58-96-8/Uridine; 63-91-2/Phenylalanine; 63231-63-0/RNA; 65-86-1/Orotic Acid; 7004-03-7/Valine; 7006-33-9/Ornithine; 73-24-5/Adenine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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