Document Detail

Uptake of amino acids and nucleic acid precursors by regenerating rat liver.
MedLine Citation:
PMID:  4119044     Owner:  NLM     Status:  MEDLINE    
1. At 0.5-1.0h after partial hepatectomy the intracellular acid-soluble fraction of rat liver took up twice as much radioactivity from [(3)H]orotic acid, [(3)H]uridine and [(3)H]thymidine as did similar fractions from sham-operated animals. This increase in penetration was not prevented by adrenalectomy or actinomycin, both of which decreased precursor uptake into nuclear RNA at this time. The increase in entry was still shown by thymidine at 22h after operation, at the height of the S period. Adenine penetration was not increased 1h after partial hepatectomy. 2. Plasma concentrations of ornithine and possibly methionine, tyrosine and lysine were raised 1.5h after partial hepatectomy. [(3)H]Lysine entry into regenerating liver at this time was increased by 60%; [(3)H]valine uptake was unaffected. Intracellular amounts of tyrosine, phenylalanine and ornithine in the liver were also increased. 3. The relation of these events to the start of liver regeneration is discussed.
M G Ord; L A Stocken
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  129     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1972 Aug 
Date Detail:
Created Date:  1973-03-08     Completed Date:  1973-03-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  175-81     Citation Subset:  IM    
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MeSH Terms
Adenine / metabolism
Amino Acids / metabolism*
Liver / metabolism
Liver Regeneration*
Lysine / metabolism
Ornithine / metabolism
Orotic Acid / metabolism*
Phenylalanine / metabolism
Thymidine / metabolism*
Tyrosine / metabolism
Uridine / metabolism*
Valine / metabolism
Reg. No./Substance:
0/Amino Acids; 10028-17-8/Tritium; 50-76-0/Dactinomycin; 50-89-5/Thymidine; 55520-40-6/Tyrosine; 56-87-1/Lysine; 58-96-8/Uridine; 63-91-2/Phenylalanine; 63231-63-0/RNA; 65-86-1/Orotic Acid; 7004-03-7/Valine; 7006-33-9/Ornithine; 73-24-5/Adenine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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