Document Detail


Uptake of albendazole and albendazole sulphoxide by Haemonchus contortus and Fasciola hepatica in sheep.
MedLine Citation:
PMID:  11078946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pattern of in vivo uptake of albendazole (ABZ) and its major metabolite, ABZ-sulphoxide (ABZSO), by Haemonchus contortus and Fasciola hepatica recovered from ABZ-treated sheep, was investigated. Concentration profiles of both compounds were simultaneously measured in target tissues/fluids from the same infected sheep. In addition, the proportion of the (+) and (-) ABZSO enantiomers was determined in plasma, bile and F. hepatica recovered from treated sheep. Sheep naturally infected with H. contortus were intraruminally (i.r.) treated with ABZ (micronized suspension, 7. 5mg/kg) and the plasma concentrations of ABZSO and ABZ-sulphone (ABZSO(2)) determined in addition to the concentration of ABZ and ABZSO in H. contortus, abomasal mucosa and fluid content samples. In addition, F. hepatica artificially infected sheep were treated i.r. with the same ABZ suspension (7.5mg/kg), and samples of blood, bile, liver tissue and adult flukes were collected and analysed by HPLC to determine the concentrations of ABZ and both enantiomers of ABZSO. ABZSO and ABZSO(2) were the analytes recovered in plasma with ABZ and ABZSO present in H. contortus. ABZ was the analyte recovered at the highest concentration in H. contortus and abomasal mucosa, whereas higher concentrations of ABZSO were measured in abomasal fluid content. Only low concentrations of ABZ were detected in F. hepatica and bile, but markedly higher concentrations of ABZ were measured in liver tissue. ABZSO was the main molecule recovered in F. hepatica, plasma and bile samples collected from ABZ-treated sheep. The (+) enantiomer of ABZSO was recovered at a higher proportion in plasma (75%), bile (78%) and F. hepatica (74%) after ABZ administration to infected sheep.
Authors:
L I Alvarez; F A Imperiale; S F Sánchez; G A Murno; C E Lanusse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary parasitology     Volume:  94     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-02-15     Completed Date:  2001-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  75-89     Citation Subset:  IM    
Affiliation:
Area Farmacología Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro, Campus Universitario, 7000, Tandil, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Abomasum / parasitology
Albendazole / administration & dosage,  analysis,  pharmacokinetics*,  therapeutic use
Animals
Anthelmintics / administration & dosage,  analysis,  pharmacokinetics*,  therapeutic use
Blood Proteins / analysis
Chromatography, High Pressure Liquid / veterinary
Fasciola hepatica / growth & development,  metabolism*
Fascioliasis / drug therapy,  parasitology,  veterinary*
Glutamate Dehydrogenase / blood
Haemonchiasis / drug therapy,  parasitology,  veterinary*
Haemonchus / growth & development,  metabolism*
Male
Serum Albumin / analysis
Serum Globulins / analysis
Sheep
Sheep Diseases / blood,  drug therapy,  parasitology*
Stereoisomerism
gamma-Glutamyltransferase / blood
Chemical
Reg. No./Substance:
0/Anthelmintics; 0/Blood Proteins; 0/Serum Albumin; 0/Serum Globulins; 54965-21-8/Albendazole; EC 1.4.1.2/Glutamate Dehydrogenase; EC 2.3.2.2/gamma-Glutamyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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