| Uptake of CDDP-containing polymeric micelles by cells using particle induced X-ray emission. | |
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MedLine Citation:
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PMID: 21187667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polymeric micelles loaded with cis-diamminedichloroplatinum(II), CDDP, (cisplatin micelles) enable higher accumulation in solid tumors and lower toxicities compared with CDDP alone. The combined use of cisplatin micelles with radiation is expected to enhance therapeutic effects and reduce side effects. The kinetics of cisplatin micelle uptake, however, have not been fully understood. Particle Induced X-Ray Emission has been employed in this study to measure the time transients of platinum in Chinese Hamster ovary cells. The results show that the platinum content of cells treated with cisplatin micelles increased more slowly than with CDDP alone, suggesting that cellular uptake could be controlled using micelles. The CDDP released from micelles was predominantly incorporated into the cells by diffusion. The uptake characteristics were further analyzed using micelles with different collapse rates. The results and techniques used in this study will be useful for designing an optimum treatment plan combining platinum-containing polymeric micelles and radiation in clinical applications. |
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Authors:
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Kazue Mizuno; Teruaki Konishi; Masakazu Oikawa; Hiroyuki Iso; Takahiro Ishikawa; Hitoshi Imaseki; Mitsuru Uesaka |
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Publication Detail:
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Type: Journal Article Date: 2010-12-24 |
Journal Detail:
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Title: Journal of radiation research Volume: 52 ISSN: 1349-9157 ISO Abbreviation: J. Radiat. Res. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-25 Completed Date: 2011-07-05 Revised Date: 2012-03-28 |
Medline Journal Info:
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Nlm Unique ID: 0376611 Medline TA: J Radiat Res Country: Japan |
Other Details:
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Languages: eng Pagination: 193-8 Citation Subset: IM |
Affiliation:
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Department of Nuclear Engineering and Management, School of Engineering, The University of Tokyo, Japan. mizuno@nuclear.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / pharmacokinetics* Biological Transport CHO Cells Cisplatin / pharmacokinetics* Cricetinae Cricetulus Diffusion Female Kinetics Micelles* Models, Biological Phenols / pharmacology* Time Factors X-Rays |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Micelles; 0/Phenols; 15663-27-1/Cisplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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