Document Detail

Uptake of CDDP-containing polymeric micelles by cells using particle induced X-ray emission.
MedLine Citation:
PMID:  21187667     Owner:  NLM     Status:  MEDLINE    
Polymeric micelles loaded with cis-diamminedichloroplatinum(II), CDDP, (cisplatin micelles) enable higher accumulation in solid tumors and lower toxicities compared with CDDP alone. The combined use of cisplatin micelles with radiation is expected to enhance therapeutic effects and reduce side effects. The kinetics of cisplatin micelle uptake, however, have not been fully understood. Particle Induced X-Ray Emission has been employed in this study to measure the time transients of platinum in Chinese Hamster ovary cells. The results show that the platinum content of cells treated with cisplatin micelles increased more slowly than with CDDP alone, suggesting that cellular uptake could be controlled using micelles. The CDDP released from micelles was predominantly incorporated into the cells by diffusion. The uptake characteristics were further analyzed using micelles with different collapse rates. The results and techniques used in this study will be useful for designing an optimum treatment plan combining platinum-containing polymeric micelles and radiation in clinical applications.
Kazue Mizuno; Teruaki Konishi; Masakazu Oikawa; Hiroyuki Iso; Takahiro Ishikawa; Hitoshi Imaseki; Mitsuru Uesaka
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Publication Detail:
Type:  Journal Article     Date:  2010-12-24
Journal Detail:
Title:  Journal of radiation research     Volume:  52     ISSN:  1349-9157     ISO Abbreviation:  J. Radiat. Res.     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-25     Completed Date:  2011-07-05     Revised Date:  2012-03-28    
Medline Journal Info:
Nlm Unique ID:  0376611     Medline TA:  J Radiat Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
Department of Nuclear Engineering and Management, School of Engineering, The University of Tokyo, Japan.
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MeSH Terms
Antineoplastic Agents / pharmacokinetics*
Biological Transport
CHO Cells
Cisplatin / pharmacokinetics*
Models, Biological
Phenols / pharmacology*
Time Factors
Reg. No./Substance:
0/Antineoplastic Agents; 0/Micelles; 0/Phenols; 15663-27-1/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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