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Uptake of 5-hydroxy[14C]tryptophan by rat and dog brain slices.
MedLine Citation:
PMID:  19108173     Owner:  PIP     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Slices of rat brain take up and concentrate 5-hydroxy[(14)C]tryptophan when incubated at 37 degrees C in vitro. Uptake is inhibited by methyldopa and L-phenylalanine in a competitive manner. Only a small proportion of the 5-hydroxy[(14)C]tryptophan taken up is decarboxylated. This observation, and the lack of correlation between the effects of various amino-acid inhibitors on uptake and on decarboxylase, suggest that the two processes are not linked. In the cold some passive diffusion of the amino-acid occurs, as is thought to take place also at 37 degrees C. Experiments with dog brain show that uptake varies from one part of the brain to another, being greatest in the caudate nucleus. The possible implications of the uptake mechanism in the treatment of animals or patients with large doses of amino-acids are discussed.
Authors:
S E Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology and chemotherapy     Volume:  20     ISSN:  0366-0826     ISO Abbreviation:  Br J Pharmacol Chemother     Publication Date:  1963 Feb 
Date Detail:
Created Date:  2009-07-29     Completed Date:  2009-07-29     Revised Date:  2010-09-23    
Medline Journal Info:
Nlm Unique ID:  0154627     Medline TA:  Br J Pharmacol Chemother     Country:  England    
Other Details:
Languages:  eng     Pagination:  178-89     Citation Subset:  -    
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