Document Detail

Upstream stimulating factors: highly versatile stress-responsive transcription factors.
MedLine Citation:
PMID:  16162174     Owner:  NLM     Status:  MEDLINE    
Upstream stimulating factors (USF), USF-1 and USF-2, are members of the eucaryotic evolutionary conserved basic-Helix-Loop-Helix-Leucine Zipper transcription factor family. They interact with high affinity to cognate E-box regulatory elements (CANNTG), which are largely represented across the whole genome in eucaryotes. The ubiquitously expressed USF-transcription factors participate in distinct transcriptional processes, mediating recruitment of chromatin remodelling enzymes and interacting with co-activators and members of the transcription pre-initiation complex. Results obtained from both cell lines and knock-out mice indicates that USF factors are key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism, and in melanocytes USF-1 has been implicated as a key UV-activated regulator of genes associated with pigmentation. This review will focus on general characteristics of the USF-transcription factors and their place in some regulatory networks.
Sébastien Corre; Marie-Dominique Galibert
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society     Volume:  18     ISSN:  0893-5785     ISO Abbreviation:  Pigment Cell Res.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-15     Completed Date:  2005-10-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8800247     Medline TA:  Pigment Cell Res     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  337-48     Citation Subset:  IM    
CNRS UMR 6061 Laboratoire de Génétique et Développement, Faculté de Médecine, Université de Rennes-1, Rennes Cedex, France.
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MeSH Terms
Cell Cycle
DNA-Binding Proteins / chemistry,  genetics,  physiology*
E-Box Elements
Gene Expression Regulation / genetics,  radiation effects
Genes, Tumor Suppressor
Glucose / metabolism
Helix-Loop-Helix Motifs
Lymphocyte Activation
Melanins / biosynthesis
Melanocytes / physiology*,  radiation effects
Mice, Knockout
Promoter Regions, Genetic
Signal Transduction / radiation effects
Transcription Factors / chemistry,  genetics,  physiology*
Transcription, Genetic*
Ultraviolet Rays
Upstream Stimulatory Factors
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Melanins; 0/Transcription Factors; 0/USF1 protein, human; 0/Upstream Stimulatory Factors; 0/Usf1 protein, mouse; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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