Document Detail

Upstream effect for atrial fibrillation: still a dilemma?
MedLine Citation:
PMID:  21029134     Owner:  NLM     Status:  In-Process    
Atrial fibrillation is the most common arrhythmia in clinical practice. Ion channel blocking agents are often characterized by limited long-term efficacy and several side effects. In addition, ablative invasive procedures are neither easily accessible nor always efficacious. The "upstream therapy," which includes angiotensin-converting enzyme inhibitors, aldosterone receptor antagonists, statins, glucocorticoids, and ω-3 poly-unsaturated fatty acids, targets arrhythmia substrate, influencing atrial structural and electrical remodeling that play an essential role in atrial fibrillation induction and maintenance. The mechanisms involved and the most important clinical evidence regarding the upstream therapy influence on atrial fibrillation are presented in this review. Some open questions are also proposed.
Leonardo Calò; Annamaria Martino; Luigi Sciarra; Antonio Ciccaglioni; Ermenegildo De Ruvo; Lucia De Luca; Antonella Sette; Giuseppe Giunta; Ernesto Lioy; Francesco Fedele
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Publication Detail:
Type:  Journal Article     Date:  2010-10-28
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  34     ISSN:  1540-8159     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-28     Citation Subset:  IM    
Copyright Information:
©2010, The Authors. Journal compilation ©2010 Wiley Periodicals, Inc.
Division of Cardiology, Policlinico Casilino ASL RMB, Rome, Italy.
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