Document Detail

Upright posture and maximal exercise increase platelet aggregability and prostacyclin production in healthy male subjects.
MedLine Citation:
PMID:  10597849     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It is well accepted that heavy physical exertion can trigger the onset of myocardial infarction, but the mechanism is uncertain. As platelet and endothelial function play an important role in thrombotic events, platelet and prostacyclin responses to maximal treadmill exercise were studied. METHODS/RESULTS: The study subjects were 40 healthy men, mean (SEM) age 29 (5) years. Platelet aggregation was measured on a four channel aggregometer. Plasma 6-keto-prostaglandin F1alpha was analysed using an enzyme immunoassay technique. Upright posture and exercise produced an increase in platelet aggregability, as indicated by a fall in the threshold concentration of adrenaline (epinephrine) from 7.6 (1.5) microM at rest to 4.3 (1.0) microM after exercise (p = 0.002). The collagen lag time became significantly shorter with exercise (from 79.1 (3.1) seconds at rest to 71.9 (2.6) seconds after exercise, p = 0.003). Exercise was also associated with a 55% increase in plasma 6-keto-prostaglandin F1alpha (from 38.1 (75%CI 29.0 to 46.5) pg/ml at rest to 59.2 (47.3 to 66.8) pg/ml after exercise, p<0.001). CONCLUSIONS: In healthy male subjects, upright posture and maximal exercise increased platelet aggregability but this increase was counteracted by an increase in prostacyclin production. In patients with endothelial dysfunction, a reduced prostacyclin response to exercise may promote a transient prothrombotic imbalance that may trigger cardiovascular disease onset.
D L Feng; J Murillo; P Jadhav; C McKenna; O C Gebara; I Lipinska; J E Muller; G H Tofler
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of sports medicine     Volume:  33     ISSN:  0306-3674     ISO Abbreviation:  Br J Sports Med     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-19     Completed Date:  2000-01-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0432520     Medline TA:  Br J Sports Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  401-4     Citation Subset:  IM; S    
Institute for Prevention of Cardiovascular Disease, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
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MeSH Terms
Biological Markers / blood
Exercise Test
Physical Exertion / physiology*
Platelet Aggregation / physiology*
Platelet Count
Posture / physiology*
Prostaglandins / biosynthesis*,  blood
Reference Values
Sensitivity and Specificity
Statistics, Nonparametric
Reg. No./Substance:
0/Biological Markers; 0/Prostaglandins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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