Document Detail


Upregulation of vascular growth factors in multiple sclerosis: correlation with MRI findings.
MedLine Citation:
PMID:  16376944     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vascular permeability changes precede the development of demyelinating lesions in multiple sclerosis (MS), and vessel wall thickening and capillary proliferation are frequently seen in autopsied MS lesions. Although vascular growth factors are critical for inducing such vascular changes, their involvement in MS has not been extensively studied. Thus, we examined the involvement of various vascular growth factors in MS according to their clinical phase and subtype. We measured serum levels of vascular endothelial growth factor (VEGF), acidic and basic fibroblast growth factors (FGF) and platelet-derived growth factors (PDGFs)-AA, -AB and -BB in 50 patients with MS (27 opticospinal MS and 23 conventional MS patients) and 33 healthy controls using sandwich enzyme immunoassays. Correlations between growth factor changes and brain and spinal cord MRI findings were then analyzed. Serum VEGF concentrations were significantly higher in MS patients in relapse than in controls (p = 0.0495) and in MS patients in remission (p = 0.0003), irrespective of clinical subtype. Basic FGF was significantly increased in conventional MS patients, but not opticospinal MS patients compared with controls (p = 0.0291), irrespective of clinical phase. VEGF at relapse showed a significant positive correlation with the length of spinal cord lesions on MRI (r = 0.506, p = 0.0319). The results suggest that an increase in serum VEGF concentration might be involved in MS relapse and the formation of longitudinally extensive spinal cord lesions.
Authors:
Jen Jen Su; Manabu Osoegawa; Takeshi Matsuoka; Motozumi Minohara; Masahito Tanaka; Takaaki Ishizu; Futoshi Mihara; Takayuki Taniwaki; Jun-ichi Kira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-27
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  243     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-22     Completed Date:  2006-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  21-30     Citation Subset:  IM    
Affiliation:
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Vessels / metabolism*,  physiopathology
Blood-Brain Barrier / metabolism,  physiopathology
Brain / pathology,  physiopathology
Central Nervous System / blood supply,  pathology*,  physiopathology
Disease Progression
Female
Fibroblast Growth Factor 2 / blood
Growth Substances / blood*
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis / blood*,  diagnosis*,  physiopathology
Neovascularization, Pathologic / blood*,  physiopathology
Neuromyelitis Optica / blood,  diagnosis,  physiopathology
Platelet-Derived Growth Factor / metabolism
Recurrence
Spinal Cord / pathology,  physiopathology
Up-Regulation / physiology*
Vascular Endothelial Growth Factor A / blood
Chemical
Reg. No./Substance:
0/Growth Substances; 0/Platelet-Derived Growth Factor; 0/Vascular Endothelial Growth Factor A; 0/platelet-derived growth factor A; 0/platelet-derived growth factor AB; 0/platelet-derived growth factor BB; 103107-01-3/Fibroblast Growth Factor 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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