Document Detail


Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis.
MedLine Citation:
PMID:  17959848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus-associated respiratory disease in early life.
Authors:
Carolina Scagnolari; Fabio Midulla; Simona Trombetti; Alessandra Pierangeli; Valeria Tromba; Rosanna Grossi; Paola Di Marco; Caterina Dianzani; Enrico Girardi; Guido Antonelli
Related Documents :
8240758 - Nitrogen dioxide and respiratory illness in children. part i: health outcomes.
24445838 - The effect of birth-month on the risk of rsv hospitalization in the first year of life ...
10836158 - Neonatal acute respiratory failure.
22492388 - The apparent breastfeeding paradox in very preterm infants: relationship between breast...
12169828 - Early gastrointestinal function and nutritional status in preterm infants with cystic p...
9891618 - Endocrine assays to predict preterm delivery.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  232     ISSN:  1535-3702     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-25     Completed Date:  2008-03-14     Revised Date:  2008-05-30    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1355-9     Citation Subset:  IM    
Affiliation:
Department of Experimental Medicine, Virology Section, Sapienza University of Rome, 00185 Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bronchiolitis / genetics*,  physiopathology,  virology
Cytokines / genetics
Gene Expression Regulation* / drug effects
Humans
Infant
Interferons / pharmacology*
Oxygen Consumption
Polymerase Chain Reaction
Respiratory Syncytial Viruses / isolation & purification
Rhinovirus / isolation & purification
Chemical
Reg. No./Substance:
0/Cytokines; 9008-11-1/Interferons
Comments/Corrections
Comment In:
Exp Biol Med (Maywood). 2008 May;233(5):493-4; discussion 495   [PMID:  18434613 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5-(4-pheno...
Next Document:  Adrenergic response of splanchnic arteries from cirrhotic patients: role of nitric oxide, prostanoid...