| Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis. | |
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MedLine Citation:
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PMID: 17959848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus-associated respiratory disease in early life. |
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Authors:
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Carolina Scagnolari; Fabio Midulla; Simona Trombetti; Alessandra Pierangeli; Valeria Tromba; Rosanna Grossi; Paola Di Marco; Caterina Dianzani; Enrico Girardi; Guido Antonelli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental biology and medicine (Maywood, N.J.) Volume: 232 ISSN: 1535-3702 ISO Abbreviation: Exp. Biol. Med. (Maywood) Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-25 Completed Date: 2008-03-14 Revised Date: 2008-05-30 |
Medline Journal Info:
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Nlm Unique ID: 100973463 Medline TA: Exp Biol Med (Maywood) Country: United States |
Other Details:
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Languages: eng Pagination: 1355-9 Citation Subset: IM |
Affiliation:
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Department of Experimental Medicine, Virology Section, Sapienza University of Rome, 00185 Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bronchiolitis
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genetics*,
physiopathology,
virology Cytokines / genetics Gene Expression Regulation* / drug effects Humans Infant Interferons / pharmacology* Oxygen Consumption Polymerase Chain Reaction Respiratory Syncytial Viruses / isolation & purification Rhinovirus / isolation & purification |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 9008-11-1/Interferons |
| Comments/Corrections | |
Comment In:
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Exp Biol Med (Maywood). 2008 May;233(5):493-4; discussion 495
[PMID:
18434613
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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