Document Detail

Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis.
MedLine Citation:
PMID:  17959848     Owner:  NLM     Status:  MEDLINE    
To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus-associated respiratory disease in early life.
Carolina Scagnolari; Fabio Midulla; Simona Trombetti; Alessandra Pierangeli; Valeria Tromba; Rosanna Grossi; Paola Di Marco; Caterina Dianzani; Enrico Girardi; Guido Antonelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  232     ISSN:  1535-3702     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-25     Completed Date:  2008-03-14     Revised Date:  2008-05-30    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1355-9     Citation Subset:  IM    
Department of Experimental Medicine, Virology Section, Sapienza University of Rome, 00185 Rome, Italy.
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MeSH Terms
Bronchiolitis / genetics*,  physiopathology,  virology
Cytokines / genetics
Gene Expression Regulation* / drug effects
Interferons / pharmacology*
Oxygen Consumption
Polymerase Chain Reaction
Respiratory Syncytial Viruses / isolation & purification
Rhinovirus / isolation & purification
Reg. No./Substance:
0/Cytokines; 9008-11-1/Interferons
Comment In:
Exp Biol Med (Maywood). 2008 May;233(5):493-4; discussion 495   [PMID:  18434613 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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