Document Detail


Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice.
MedLine Citation:
PMID:  18374609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cognitive functions usually involve various synaptic proteins and neurotrophic factors in the hippocampus. However, whether treadmill exercise can improve learning and memory by upregulating some of these molecules remain unraveled. To address this question, male BALB/c mice were divided into control and exercise groups, the latter group went through 4 weeks of treadmill exercise training. At the end of exercise training period, they were either tested for passive avoidance (PA) performance or sacrificed for quantifying the hippocampal levels of brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB, the BDNF receptor), synaptotagmin (a Ca(2+)-dependent synaptic vesicle protein), and SNAP-25 (a presynaptic vesicular fusion protein). Our results showed that treadmill exercise training (1) increased the retention latency without affecting the fear acquisition in the PA test, (2) transiently increased the hippocampal BDNF level at 1, 2, and 4h after the completion of exercise training, and (3) persistently increased the hippocampal protein levels of full-length TrkB, phosphorylated TrkB and synaptotagmin, but not truncated TrkB or SNAP-25. Moreover, the protein expression level of full-length TrkB or synaptotagmin was positively correlated with PA performance in mice. Finally, inhibition of TrkB signaling by K252a abolished the exercise-facilitated PA performance and upregulation of TrkB and synaptotagmin. Taken together, these data suggest that the upregulation of TrkB and synaptotagmin in the hippocampus contributes to the exercise-facilitated aversive memory.
Authors:
Yu-Fan Liu; Hsiun-ing Chen; Lung Yu; Yu-Min Kuo; Fong-Sen Wu; Jih-Ing Chuang; Pao-Chi Liao; Chauying J Jen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-18
Journal Detail:
Title:  Neurobiology of learning and memory     Volume:  90     ISSN:  1095-9564     ISO Abbreviation:  Neurobiol Learn Mem     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-10     Completed Date:  2008-09-03     Revised Date:  2012-06-01    
Medline Journal Info:
Nlm Unique ID:  9508166     Medline TA:  Neurobiol Learn Mem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-9     Citation Subset:  IM    
Affiliation:
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Avoidance Learning / physiology*
Brain-Derived Neurotrophic Factor / metabolism
Carbazoles / pharmacology
Corticosterone / blood
Enzyme Inhibitors / pharmacology
Hippocampus / physiology*
Indole Alkaloids / pharmacology
Male
Membrane Glycoproteins / antagonists & inhibitors,  metabolism*
Memory / physiology*
Mice
Mice, Inbred BALB C
Physical Conditioning, Animal / physiology*
Protein-Tyrosine Kinases / antagonists & inhibitors,  metabolism*
Running / physiology
Synaptosomal-Associated Protein 25 / metabolism
Synaptotagmin I / metabolism*
Up-Regulation / physiology
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/Carbazoles; 0/Enzyme Inhibitors; 0/Indole Alkaloids; 0/Membrane Glycoproteins; 0/Synaptosomal-Associated Protein 25; 0/Synaptotagmin I; 0/Syt1 protein, mouse; 50-22-6/Corticosterone; 97161-97-2/staurosporine aglycone; EC 2.7.10.1/Ntrk2 protein, mouse; EC 2.7.10.1/Protein-Tyrosine Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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