Document Detail


Upregulation of Ugt1a genes in placentas and fetal livers in a murine model of assisted reproduction.
MedLine Citation:
PMID:  22115498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genes from Ugt1a family in placenta and fetal liver are responsible for hormone, nutrient and chemical balance during pregnancy. Assisted reproduction technologies (ART) i.e. intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) alter steroid homeostasis in pregnancy through increased glucuronidation. Here we show that ART (particularly ICSI) upregulates Ugt1a1, 1a2, 1a6 and 1a9 expression in murine placentas and fetal livers with higher mRNA related to lower progesterone (1a1) and cholesterol (1a2, 1a6) in placentas. Greater steroid clearance in ART through transcriptional upregulation of Ugt1a in the placental-fetal unit may decrease the availability of essential molecules, mediating negative reproductive outcomes.
Authors:
A C Collier; K A Milam; L R A Rougée; A Sugawara; Y Yamauchi; M A Ward
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-11-25
Journal Detail:
Title:  Placenta     Volume:  33     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-30     Completed Date:  2012-05-11     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholesterol / metabolism
Crosses, Genetic
Disease Models, Animal
Female
Fertilization in Vitro*
Glucuronosyltransferase / genetics,  metabolism*
Infertility, Female / enzymology,  metabolism*,  therapy
Isoenzymes / genetics,  metabolism
Liver / embryology,  enzymology,  metabolism*
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Placenta / enzymology,  metabolism*
Pregnancy
Pregnancy Proteins / genetics,  metabolism*
Progesterone / metabolism
Sperm Injections, Intracytoplasmic*
Up-Regulation
Grant Support
ID/Acronym/Agency:
NS060901/NS/NINDS NIH HHS; P20 RR024206/RR/NCRR NIH HHS; P20 RR024206-04/RR/NCRR NIH HHS; P20RR024206/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Isoenzymes; 0/Pregnancy Proteins; 4G7DS2Q64Y/Progesterone; 97C5T2UQ7J/Cholesterol; EC 2.4.1.-/UDP-glucuronosyltransferase, UGT1A6; EC 2.4.1.-/UGT1A1 enzyme; EC 2.4.1.17/Glucuronosyltransferase; EC 2.4.1.17/UDP-glucuronosyltransferase 1A9
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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