| Upregulation of Ugt1a genes in placentas and fetal livers in a murine model of assisted reproduction. | |
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MedLine Citation:
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PMID: 22115498 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Genes from Ugt1a family in placenta and fetal liver are responsible for hormone, nutrient and chemical balance during pregnancy. Assisted reproduction technologies (ART) i.e. intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) alter steroid homeostasis in pregnancy through increased glucuronidation. Here we show that ART (particularly ICSI) upregulates Ugt1a1, 1a2, 1a6 and 1a9 expression in murine placentas and fetal livers with higher mRNA related to lower progesterone (1a1) and cholesterol (1a2, 1a6) in placentas. Greater steroid clearance in ART through transcriptional upregulation of Ugt1a in the placental-fetal unit may decrease the availability of essential molecules, mediating negative reproductive outcomes. |
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Authors:
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A C Collier; K A Milam; L R A Rougée; A Sugawara; Y Yamauchi; M A Ward |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-23 |
Journal Detail:
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Title: Placenta Volume: - ISSN: 1532-3102 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Dept. Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii at Mānoa, Honolulu, HI 96813, United States; Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii at Mānoa, Honolulu, HI 96813, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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