Document Detail


Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.
MedLine Citation:
PMID:  22927819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the vitamin A metabolite retinoic acid (RA) plays a critical role in immune function, RA synthesis during infection is poorly understood. Here, we show that retinal dehydrogenases (Raldh), required for the synthesis of RA, are induced during a retinoid-dependent type-2 immune response elicited by Schistosoma mansoni infection, but not during a retinoid-independent anti-viral immune response. Vitamin A deficient mice have a selective defect in T(H)2 responses to S. mansoni, but retained normal LCMV specific T(H)1 responses. A combination of in situ imaging, intra-vital imaging, and sort purification revealed that alternatively activated macrophages (AAMφ) express high levels of Raldh2 during S. mansoni infection. IL-4 induces Raldh2 expression in bone marrow-derived macrophages in vitro and peritoneal macrophages in vivo. Finally, in vivo derived AAMφ have an enhanced capacity to induce Foxp3 expression in CD4+ cells through an RA dependent mechanism, especially in combination with TGF-β. The regulation of Raldh enzymes during infection is pathogen specific and reflects differential requirements for RA during effector responses. Specifically, AAMφ are an inducible source of RA synthesis during helminth infections and T(H)2 responses that may be important in regulating immune responses.
Authors:
Mara J Broadhurst; Jacqueline M Leung; K C Lim; Natasha M Girgis; Uma Mahesh Gundra; Padraic G Fallon; Mary Premenko-Lanier; James H McKerrow; Joseph M McCune; P'ng Loke
Related Documents :
24099299 - Regulation of th17 maturation by interleukin 4.
23878189 - Interferon-α suppresses camp to disarm human regulatory t cells.
23684299 - Did cholera toxin finally get caught?
23289719 - Modulation of bacterial ghosts--induced nitric oxide production in macrophages by bacte...
24043209 - Why money will not cure under-immunization.
25118589 - Rasgrp3 limits toll-like receptor-triggered inflammatory response in macrophages by act...
22641679 - A new method for rapid cytotoxic t-lymphocyte induction using a multiple cytokine cockt...
24099299 - Regulation of th17 maturation by interleukin 4.
8184489 - Lipocortin-1: cellular mechanisms and clinical relevance.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-23
Journal Detail:
Title:  PLoS pathogens     Volume:  8     ISSN:  1553-7374     ISO Abbreviation:  PLoS Pathog.     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-28     Completed Date:  2012-12-17     Revised Date:  2014-04-07    
Medline Journal Info:
Nlm Unique ID:  101238921     Medline TA:  PLoS Pathog     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1002883     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Forkhead Transcription Factors / biosynthesis,  genetics,  immunology
Gene Expression Regulation, Enzymologic / genetics,  immunology*
Macrophage Activation / genetics,  immunology*
Macrophages, Peritoneal / immunology*
Mice
Mice, Knockout
Retinal Dehydrogenase / biosynthesis,  genetics,  immunology*
Schistosoma mansoni / immunology*,  metabolism
Schistosomiasis mansoni / enzymology,  genetics,  immunology*
Th1 Cells / immunology
Th2 Cells / immunology
Up-Regulation / genetics,  immunology*
Grant Support
ID/Acronym/Agency:
AI093811/AI/NIAID NIH HHS; DP1 OD000329/OD/NIH HHS; OD000329/OD/NIH HHS; R01 AI093811/AI/NIAID NIH HHS; R21 AI094166/AI/NIAID NIH HHS; T32 AI007180/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Forkhead Transcription Factors; 0/Foxp3 protein, mouse; EC 1.2.1.36/Retinal Dehydrogenase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Surface ?-1,3-glucan facilitates fungal stealth infection by interfering with innate immunity in pla...
Next Document:  Ago HITS-CLIP expands understanding of Kaposi's sarcoma-associated herpesvirus miRNA function in pri...