| Upregulation of IL-17, but not of IL-9, in circulating cells of CIS and relapsing MS patients. Impact of corticosteroid therapy on the cytokine network. | |
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MedLine Citation:
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PMID: 22245284 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The concomitant production of IL-17A and IL-9, both Th17 cytokines, has not been compared in MS patients. We show that IL-17A but not IL-9 expression by CD3(+) cells was increased during a MS relapse. Co-expression of IL-17A and IL-9 was marginal. In addition to Th1 and Th2 cytokines, IL-17A, IL-6 and IL-23p19 were down-regulated by ivMP, but Foxp3 was not, while an increase in IL-10, TGF-β1 and IL-27p28 mRNA was observed. This change in the Th17, Treg and IL-10 balance could be an additional mechanism by which corticosteroids shorten the duration of a MS relapse and promote recovery. |
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Authors:
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Nathalie Muls; Karima Jnaoui; Hong Anh Dang; Antony Wauters; Jacques Van Snick; Christian Jean-Marie Sindic; Vincent van Pesch |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-13 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: - ISSN: 1872-8421 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Unité de Neurochimie, Institute of Neuroscience, Avenue Mounier, 53 (BP 53.02), Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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