| Upregulation of fractalkine and its receptor, CX3CR1, is associated with coronary plaque rupture in patients with unstable angina pectoris. | |
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MedLine Citation:
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PMID: 20019415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Recent studies suggest that fractalkine (FKN or CX3CL1) and its cognate receptor, CX3CR1, play a role in atherogenesis, so the relationship between coronary plaque rupture, as observed by preintervention optical coherence tomography, and plasma levels of FKN and CX3CR1 was investigated in this study. METHODS AND RESULTS: The study population consisted of 46 patients with unstable angina pectoris (UAP), 30 patients with stable angina pectoris, and 25 healthy controls. The UAP patients underwent a preintervention optical coherence tomography study, which revealed that the number of patients with and without plaque rupture at the culprit site was 27 (rupture group) and 19 (non-rupture group), respectively. Plasma levels of soluble FKN (sFKN) and CX3CR1 were measured by enzyme-linked immunosorbent assay and flow cytometry, respectively. The plasma levels of sFKN were significantly increased in UAP patients with plaque rupture compared with patients in the other groups. Multiple logistic regression analysis showed that CD14(+)CD16(+)CX3CR1(+) monocytes and CD3(+)CX3CR1(+) lymphocytes were independent predictors of the presence of ruptured plaque. CONCLUSIONS: Increases in the FKN level and the number of CX3CR1-expressing mononuclear cells might contribute to coronary plaque rupture. |
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Authors:
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Hideyuki Ikejima; Toshio Imanishi; Hiroto Tsujioka; Manabu Kashiwagi; Akio Kuroi; Takashi Tanimoto; Hironori Kitabata; Kohei Ishibashi; Kenichi Komukai; Tatsuya Takeshita; Takashi Akasaka |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-17 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 74 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-25 Completed Date: 2010-03-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 337-45 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina, Unstable / diagnosis, immunology* Antigens, CD14 / analysis Antigens, CD3 / analysis Biological Markers / blood Chemokine CX3CL1 / blood* Coronary Angiography Coronary Artery Disease / complications, diagnosis, immunology* Disease Progression Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Humans Logistic Models Lymphocytes / immunology Male Middle Aged Monocytes / immunology Odds Ratio Receptors, Chemokine / blood* Receptors, IgG / analysis Risk Assessment Risk Factors Rupture Tomography, Optical Coherence Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD14; 0/Antigens, CD3; 0/Biological Markers; 0/CX3CL1 protein, human; 0/CX3CR1 protein, human; 0/Chemokine CX3CL1; 0/FCGR3B protein, human; 0/Receptors, Chemokine; 0/Receptors, IgG |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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