| Upregulation of Beclin 1 in the ischemic penumbra. | |
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MedLine Citation:
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PMID: 18075295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Here we discuss the probable role of autophagy in cerebral ischemia based on our own recent data and the literature. We examined the protein level of Beclin 1 (Bcl-2 interacting protein) and microtubule-associated protein 1 light chain 3 (LC3) which were previously found to promote autophagy. We found a dramatic elevation in Beclin 1 levels and LC3 in the penumbra of rats challenged by cerebral ischemia. We found also that a subpopulation of Beclin 1-upregulating cells is also expressing the active form of caspase-3, and that all Beclin 1 upregulating cells display dense staining of LC3. Neuronal cells that overexpress Beclin 1 may exhibit damaged DNA but without changes in nuclear morphology, which indicates that not all the Beclin 1-upregulating cells are predestined to die. We conclude that the cell death in the penumbra bears a resemblance not only to necrosis, apoptosis, or a compromise between the two, but exhibits also biochemical and morphological characteristics of autophagic cell death. The question that constantly arises, however, is whether autophagic activity in damaged cells is the cause of death or is actually an attempt to prevent it as a part of an endogenous neuroprotective response. |
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Authors:
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Abdelhaq Rami |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-11-27 |
Journal Detail:
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Title: Autophagy Volume: 4 ISSN: 1554-8635 ISO Abbreviation: Autophagy Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-21 Completed Date: 2008-03-19 Revised Date: 2011-06-30 |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: United States |
Other Details:
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Languages: eng Pagination: 227-9 Citation Subset: IM |
Affiliation:
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Institute of Cellular and Molecular Anatomy (Anatomie III), Dr. Senckenbergische Anatomie, Klinikum der Johann Wolfgang von Goethe-Universität, Franfurt/Main, Germany. Rami@em.uni-frankfurt.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Regulatory Proteins / genetics*, metabolism Autophagy / genetics Biological Markers / metabolism Brain Ischemia / genetics*, metabolism Cell Death Cerebral Cortex / metabolism* Microtubule-Associated Proteins / metabolism Models, Biological Protein Transport Rats Up-Regulation* |
| Chemical | |
Reg. No./Substance:
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0/Apoptosis Regulatory Proteins; 0/Biological Markers; 0/LC3 protein, rat; 0/Microtubule-Associated Proteins; 0/beclin 1 protein, rat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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