Document Detail

Upregulated ataxia-telangiectasia group D complementing gene correlates with poor prognosis in patients with esophageal squamous cell carcinoma.
MedLine Citation:
PMID:  23020249     Owner:  NLM     Status:  Publisher    
The ataxia-telangiectasia group D complementing gene (ATDC) plays significant roles in various human cancers. However, the clinical significance of ATDC in esophageal squamous cell carcinoma (ESCC) has not been investigated. The ATDC messenger RNA level of 40 paired ESCC and nonneoplastic tissues were evaluated using quantitative real-time polymerase chain reaction, 10 pairs of which were also used for Western blot analysis. In addition, immunohistochemical staining was performed to detect the ATDC expression in 118 paraffin-embedded cancerous and matched nonneoplastic tissues, and the correlation of ATDC expression with the clinicopathological parameters and prognosis of the ESCC patients was analyzed. The quantitative real-time polymerase chain reaction, immunohistochemical staining, and Western blot results demonstrated that the expression level of ATDC was significantly higher in ESCC tissue than in matched noncancerous tissues. Both ATDC messenger RNA and protein expression in the ESCC tissue were significantly correlated with tumor differentiation, stage, and lymph node metastasis. However, there was no significant difference in ATDC expression based on patient age or gender. Moreover, the results of both univariate and multivariate analyses showed that increased ATDC expression was correlated with a shorter 5-year survival time for ESCC patients after surgery. We concluded that increased ATDC expression is associated with poor clinical outcomes and that this marker might be a useful indicator for prognosis and a promising target for therapy in ESCC patients.
W Lai; J Zhao; C Zhang; D Cui; J Lin; Y He; H Zheng; X Wu; M Yang
Related Documents :
23098499 - Cd4+, il17 and foxp3 expression in different ptnm stages of operable non-small cell lun...
23804589 - Fat cell size and adipokine expression in relation to gender, depot and metabolic risk ...
23824569 - Stat3 is associated with lymph node metastasis in gastric cancer.
24594899 - Cloning, functional characterization and nutritional regulation of δ6 fatty acyl desat...
12529169 - Nitrogen-source regulation of yeast gamma-glutamyl transpeptidase synthesis involves th...
22282499 - Nt-pgc-1α protein is sufficient to link β3-adrenergic receptor activation to transcri...
11234879 - Preserved smad4 expression in the transforming growth factor beta signaling pathway is ...
9310319 - Feed-back mechanisms affecting notch activation at the dorsoventral boundary in the dro...
19171649 - Divergent regulation of cardiac kcnd3 potassium channel expression by the thyroid hormo...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E     Volume:  -     ISSN:  1442-2050     ISO Abbreviation:  Dis. Esophagus     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809160     Medline TA:  Dis Esophagus     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Copyright the Authors. Journal compilation © 2012, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus.
Department of Rheumatology, The Southern Medical University, Guangzhou.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Oxygen Vacancy-Assisted Coupling and Enolization of Acetaldehyde on CeO2(111).
Next Document:  Secondary health conditions and spinal cord injury: an uphill battle in the journey of care.