| Upper sphincter function during transient lower oesophageal sphincter relaxation (tLOSR); it is mainly about microburps. | |
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MedLine Citation:
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PMID: 17300290 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transient lower oesophageal sphincter relaxations (tLOSRs) are both a dominant mechanism of reflux and an element of the belch reflex. This study aimed to analyse the interplay between reflux and upper oesophageal sphincter (UOS) activity during meal-induced tLOSRs. Fifteen normal subjects were studied with a solid-state high-resolution manometry assembly positioned to record from the hypopharynx to the stomach and a catheter pH electrode 5 cm above the LOS. Subjects ate a 1000-calorie high-fat meal and were monitored for 120 min in a sitting posture. The relationship among tLOSRs, common cavities, pressure changes within the oesophagus and UOS contractile activity were analysed. A total of 218 tLOSRs occurred among the 15 subjects. The majority (79%) were coupled with UOS relaxation and 84% (145/173) of these occurred in association with a common cavity. Upper oesophageal sphincter relaxation was usually preceded by a pressure change in the oesophagus; however, some relaxations (16%) occurred without a discernable increase in pressure or before the pressure increase began. Acid reflux did not appear to play a role in determining UOS response to tLOSRs. The majority of post-prandial tLOSRs were associated with brief periods of UOS relaxation, likely permissive of gas venting (microburps). Intraoesophageal pressure changes likely modulate this UOS response; however, an anticipatory characteristic was evident in some subjects. Whether or not GORD patients with extra-oesophageal symptoms exhibit an exaggeration of the UOS relaxation response during reflux is yet to be determined. |
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Authors:
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J E Pandolfino; S K Ghosh; Q Zhang; A Han; P J Kahrilas |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 19 ISSN: 1350-1925 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-15 Completed Date: 2007-05-04 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 203-10 Citation Subset: IM |
Affiliation:
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Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. j-pandolfino@northwestern.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Eructation / physiopathology* Esophageal Sphincter, Lower / physiology* Esophageal Sphincter, Upper / physiology* Gastroesophageal Reflux / physiopathology* Humans Male Manometry Middle Aged Muscle Relaxation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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K23 DK062170-01/DK/NIDDK NIH HHS; R01 DK56033/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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