Document Detail

Upper gut dysmotility in slow-transit constipation: is it evidence for a pan-enteric neurological deficit in severe slow transit constipation?
MedLine Citation:
PMID:  10445784     Owner:  NLM     Status:  MEDLINE    
Although constipation is common only a small fraction meet the criteria of slow transit constipation. Those that do are resistant to treatment and present a significant clinical problem to the physician and surgeon. Evidence has been accumulating over many years that the impaired colonic motility is part of a generalized motility defect. There are several reports of oesophageal dysmotility, delayed gastric emptying and slow small bowel transit. These abnormalities are not secondary to a distended colon since they are still seen after colonic cleansing and even after colectomy. The manometric abnormalities of small bowel motility are hard to assess unless done over a prolonged period (24 h) because of the great variability observed. The clinical picture of slow transit constipation is quite different from chronic intestinal pseudo-obstruction and the manometric abnormalities are much less obvious. The possibility of an underlying autonomic disturbance warrants further study.
R C Spiller
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  11     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-08     Completed Date:  1999-09-08     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  693-6     Citation Subset:  IM    
Division of Gastroenterology, University Hospital, Nottingham, UK.
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MeSH Terms
Colon / innervation*
Constipation / pathology,  physiopathology*
Gastrointestinal Motility*
Gastrointestinal Transit*
Myoelectric Complex, Migrating
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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