| Upper genital tract changes and pregnancy outcome in offspring exposed in utero to diethylstilbestrol. | |
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MedLine Citation:
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PMID: 7377249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hysterosalpingography (HSG) was performed on 267 diethylstilbestrol (DES)-exposed women. One hundred eighty-five (69%) of these women demonstrated an abnormality and 82 women had normal findings. A relationship between abnormal x-ray findings and structural abnormalities of the cervix and vaginal epithelial changes was noted. Ninety-three women on whom roentgenography was performed had a total of 144 pregnancies. The pregnancy outcome in this group of women was significantly worse than that found in a control population of 87 women who had 147 pregnancies. In addition, women with abnormal x-ray films were found to have a poorer pregnancy outcome than the group of women with normal findings. The women with abnormal x-ray films had more ectopic pregnancies, spontaneous abortions, and premature deliveries than women with normal x-ray films although these differences were not statistically significant. Significantly fewer women with abnormal findings than women with normal x-rays were delivered of term infants. This study reviews the physical findings and results of hysterosalpingography in 267 women exposed in utero to diethylstilbestrol (DES); pregnancy outcome of 93 of these exposed women was correlated with the x-ray findings. Of the 267, 185 (69%) showed an upper genital tract abnormality and 82 showed normal genitalia according to the x-ray technique used. The abnormal hysterosalpingography findings found were correlated with structural abnormalities of the cervix and vaginal epithelium alterations particularly. 144 pregnancies had occurred in the 93 women who were studied by roentgenography, and pregnancy outcome in these 93 women was significantly worse in women with upper genital tract abnormalities as visualized by x-ray. For example, those with abnormal hysterosalpingograms had 78 pregnancies (vs. 66 among normal x-ray women), with 12 elective abortions (vs. 23), 5 (8%) ectopic pregnancies (vs. 2, i.e., 4%), a total of 24 spontaneous abortions (39% of pregnancies vs. only 12 or 23% in normal x-ray women), 38% (n=14) premature deliveries (vs. 8), and 23 (34%) term deliveries (vs. 58% in normals. Women with abnormal x-rays had more ectopic pregnancies and premature deliveries than normals also, though the differences were not statistically significant. Significantly fewer women with abnormal findings vs. women with normal x-ray delivered term infants. |
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Authors:
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R H Kaufman; E Adam; G L Binder; E Gerthoffer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 137 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1980 Jun |
Date Detail:
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Created Date: 1980-07-28 Completed Date: 1980-07-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 299-308 Citation Subset: AIM; IM; J |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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chemically induced Adult Cervix Uteri / drug effects* Diethylstilbestrol / adverse effects* Epithelium / drug effects Female Fetal Viability Fetus / drug effects Humans Hysterosalpingography Infant, Newborn Infant, Premature Pregnancy Pregnancy Complications / chemically induced* Pregnancy, Ectopic / chemically induced Uterus / drug effects* Vagina / drug effects* |
| Chemical | |
Reg. No./Substance:
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56-53-1/Diethylstilbestrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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