| Upper genital tract abnormalities and pregnancy outcome in diethylstilbestrol-exposed progeny. | |
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MedLine Citation:
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PMID: 6711635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have suggested that there is an association between genital tract abnormalities and pregnancy outcome in women exposed to diethylstilbestrol (DES) in utero. In a collaborative study, 676 DES-exposed women had hysterosalpingographic examinations, and the findings were related to the outcome of pregnancy in 327 of these women. The findings revealed that (1) there is a considerable variation of frequency of different types of upper genital tract anomalies in women from different sources and with different motivations for enrollment in the study, (2) the presence of structural cervical changes and vaginal epithelial changes are markers for the likelihood of abnormalities in the uterine fundus, (3) women with upper genital tract abnormalities have increased odds for poor pregnancy outcome as compared to women with normal hysterosalpingographic findings, and (4) although some abnormalities were most often or consistently associated with poor pregnancy outcome, no specific changes could be related to specific types of pregnancy outcomes. |
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Authors:
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R H Kaufman; K Noller; E Adam; J Irwin; M Gray; J A Jefferies; J Hilton |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 148 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-05-07 Completed Date: 1984-05-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 973-84 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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etiology Diethylstilbestrol / adverse effects* Female Fetal Death / etiology Genitalia, Female / abnormalities* Humans Hysterosalpingography Pregnancy Pregnancy Complications / chemically induced*, diagnosis Pregnancy, Ectopic / etiology Prenatal Exposure Delayed Effects* Uterus / abnormalities |
| Grant Support | |
ID/Acronym/Agency:
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R01-HD10989-05/HD/NICHD NIH HHS; USPH-1R10CA32236-01/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-53-1/Diethylstilbestrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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