| Upper gastrointestinal cancer in patients with familial adenomatous polyposis. | |
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MedLine Citation:
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PMID:Â 2571019 Â Â Â Owner:Â NLM Â Â Â Status:Â MEDLINE Â Â Â |
Abstract/OtherAbstract:
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102 patients with familial adenomatous polyposis underwent upper gastrointestinal endoscopy as a screening test for gastroduodenal adenomas. 100 had duodenal abnormalities (dysplasia in 94, and hyperplasia in 6), usually in the second and third parts of the duodenum (91%). The periampullary area was abnormal in 87 of 97 patients who had a biopsy specimen taken from this site (dysplasia 72, hyperplasia 13, and inflammation 2). By contrast, gastric dysplasia was found in only 6 patients. Classification of duodenal polyposis on a 5-grade scale (stages 0-IV), based on polyp number, size, histology, and severity of dysplasia, showed that 11 had stage IV disease: these patients are at greatest risk of malignant change and require close surveillance. The pattern of dysplasia observed in the upper gastrointestinal tract resembled the pattern of mucosal exposure to bile. |
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Authors:
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A D Spigelman; C B Williams; I C Talbot; P Domizio; R K Phillips |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't    |
Journal Detail:
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Title: Lancet    Volume: 2    ISSN: 0140-6736    ISO Abbreviation: Lancet    Publication Date: 1989 Sep |
Date Detail:
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Created Date:Â 1989-10-26 Â Â Â Completed Date:Â 1989-10-26 Â Â Â Revised Date:Â 2006-11-15 Â Â Â |
Medline Journal Info:
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Nlm Unique ID: 2985213R    Medline TA: Lancet    Country: ENGLAND    |
Other Details:
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Languages: eng    Pagination: 783-5    Citation Subset: AIM; IM    |
Affiliation:
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St. Mark's Hospital, London. |
Export Citation:
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APA/MLA Format    Download EndNote    Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
/
etiology*,Â
pathology Adenomatous Polyposis Coli / complications* Adolescent Adult Aged Duodenal Neoplasms / etiology*, pathology Duodenoscopy Female Humans Male Middle Aged Neoplasm Staging Prospective Studies Pyloric Antrum / pathology Retrospective Studies Risk Factors Sampling Studies Stomach Neoplasms / etiology*, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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