Document Detail

Upper gastrointestinal cancer in patients with familial adenomatous polyposis.
MedLine Citation:
PMID:  2571019     Owner:  NLM     Status:  MEDLINE    
102 patients with familial adenomatous polyposis underwent upper gastrointestinal endoscopy as a screening test for gastroduodenal adenomas. 100 had duodenal abnormalities (dysplasia in 94, and hyperplasia in 6), usually in the second and third parts of the duodenum (91%). The periampullary area was abnormal in 87 of 97 patients who had a biopsy specimen taken from this site (dysplasia 72, hyperplasia 13, and inflammation 2). By contrast, gastric dysplasia was found in only 6 patients. Classification of duodenal polyposis on a 5-grade scale (stages 0-IV), based on polyp number, size, histology, and severity of dysplasia, showed that 11 had stage IV disease: these patients are at greatest risk of malignant change and require close surveillance. The pattern of dysplasia observed in the upper gastrointestinal tract resembled the pattern of mucosal exposure to bile.
A D Spigelman; C B Williams; I C Talbot; P Domizio; R K Phillips
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-10-26     Completed Date:  1989-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  783-5     Citation Subset:  AIM; IM    
St. Mark's Hospital, London.
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MeSH Terms
Adenoma / etiology*,  pathology
Adenomatous Polyposis Coli / complications*
Duodenal Neoplasms / etiology*,  pathology
Middle Aged
Neoplasm Staging
Prospective Studies
Pyloric Antrum / pathology
Retrospective Studies
Risk Factors
Sampling Studies
Stomach Neoplasms / etiology*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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