Document Detail


Upper gastrointestinal bleeding after hip and knee arthroplasty.
MedLine Citation:
PMID:  16539204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of nonsteroidal anti-inflammatory drugs (NSAIDs) and anticoagulants increases the risk of upper gastrointestinal bleeding. This article assesses its incidence in patients undergoing hip and knee arthroplasty. A single-center, retrospective study was conducted on 100 consecutive hip and 100 consecutive knee arthroplasties performed at the Victoria Infirmary, Glasgow, between 1998 and 2000. Sixty-three percent of patients were women with a mean age of 74. Fifty-four percent of patients received NSAIDs and all patients received anticoagulants perioperatively. Four and a half percent of patients had upper gastrointestinal bleeding postoperatively. We believe that the incidence of upper gastrointestinal bleeding as a complication is underestimated and recommend gastro-protective agents in the perioperative period for patients on NSAIDs.
Authors:
Sunil Sharma
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Orthopedics     Volume:  29     ISSN:  0147-7447     ISO Abbreviation:  Orthopedics     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-16     Completed Date:  2006-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806107     Medline TA:  Orthopedics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  255-7     Citation Subset:  IM    
Affiliation:
Glasgow Royal Infirmary, Glasgow, Scotland, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  adverse effects
Anticoagulants / administration & dosage,  adverse effects
Arthroplasty, Replacement, Hip*
Arthroplasty, Replacement, Knee*
Aspirin / administration & dosage,  adverse effects
Barrett Esophagus / diagnosis,  drug therapy
Duodenal Ulcer / diagnosis,  drug therapy
Endoscopy, Gastrointestinal
Female
Gastrointestinal Hemorrhage / etiology*
Heparin, Low-Molecular-Weight / administration & dosage,  adverse effects
Humans
Length of Stay
Male
Middle Aged
Postoperative Complications*
Proton Pumps / antagonists & inhibitors
Retrospective Studies
Stomach Ulcer / diagnosis,  drug therapy
Venous Thrombosis / prevention & control
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Anticoagulants; 0/Heparin, Low-Molecular-Weight; 0/Proton Pumps; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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