Document Detail


Upper control limit of reactive oxygen species in follicular fluid beyond which viable embryo formation is not favorable.
MedLine Citation:
PMID:  20406678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Though the role of reactive oxygen species (ROS) in female infertility has been a subject of rigorous research worldwide, there is inadequate information on the cut-off value of ROS in the oocyte microenvironment beyond which ART outcome may be adversely affected. An upper ROS level in follicular fluid (FF) samples of women undergoing IVF beyond which good quality embryo formation is unlikely, is established. ROS, lipid peroxidation and total antioxidant capacity were estimated. The upper cut-off ROS level beyond which viable embryo formation is not favorable was found to be approximately 107 cps/400 microl FF. This level, determined in women with tubal factor infertility, was further validated in women with endometriosis and PCOS and correlated with fertilization and pregnancy rate and embryo quality. Summarizing, a threshold level in FF has been established for the first time beyond which ROS may be considered toxic for viable embryo formation and pregnancy outcome.
Authors:
Saikat K Jana; Narendra Babu K; Ratna Chattopadhyay; Baidyanath Chakravarty; Koel Chaudhury
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-18
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  29     ISSN:  1873-1708     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  447-51     Citation Subset:  IM    
Affiliation:
School of Medical Science and Technology, Indian Institute of Technology, Kharagpur 721302, W.B., India.
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MeSH Terms
Descriptor/Qualifier:
Adult
DNA Fragmentation
Embryo, Mammalian / metabolism*
Endometriosis / metabolism
Female
Fertilization in Vitro
Follicular Fluid / metabolism*
Humans
Infertility, Female / metabolism*
Lipid Peroxidation / physiology
Oocytes / cytology,  metabolism
Oxidative Stress / physiology
Polycystic Ovary Syndrome / metabolism
Pregnancy
Pregnancy Outcome
Reactive Oxygen Species / metabolism*
Chemical
Reg. No./Substance:
0/Reactive Oxygen Species

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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