| Upper cervical spinal cord cross-sectional area in relapsing remitting multiple sclerosis: application of a new technique for measuring cross-sectional area on magnetic resonance images. | |
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MedLine Citation:
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PMID: 17659556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To measure accurately the upper cervical cord cross-sectional area (CSA) in patients with relapsing remitting multiple sclerosis (RRMS), and normal control subjects, to address the paradox that longitudinal reduction in CSA has been detected in RRMS while reduction compared to controls has not. We hypothesized that a lack of statistical power and/or measurement sensitivity due to partial volume averaging in previous studies contributed to this paradox. MATERIALS AND METHODS: Using a technique that corrects for partial volume averaging, we measured the CSA in 35 normal controls and 35 RRMS patients. We used the total intracranial volume (TICV) to normalize the CSA and therefore reduce the normal variance and improve the statistical power. RESULTS: The mean TICV did not differ between groups. Statistical power analysis indicated that a 5% reduction in CSA in the patients could be detected with an estimated power of 0.74 before normalization and 0.9 after. The mean CSA in the patients was not reduced compared to controls after (P = 0.928) or before (P = 0.881) normalization. CONCLUSION: Using a sensitive analysis method, and apparently appropriate statistical power, we did not detect reduced CSA in RRMS patients. We hypothesize that this may be due to inflammation. |
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Authors:
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Ranbir S Mann; Cris S Constantinescu; Christopher R Tench |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 26 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-31 Completed Date: 2007-10-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 61-5 Citation Subset: IM |
Copyright Information:
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Copyright 2007 Wiley-Liss, Inc. |
Affiliation:
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Division of Clinical Neurology, University Hospital, University of Nottingham, Nottingham, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atrophy Case-Control Studies Cervical Vertebrae* Female Humans Image Processing, Computer-Assisted Imaging, Three-Dimensional Inflammation Magnetic Resonance Imaging / methods* Male Multiple Sclerosis, Relapsing-Remitting / pathology* Spinal Cord / pathology* Spinal Cord Diseases / pathology* Statistics, Nonparametric |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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