Document Detail


Upper airway length may be associated with the severity of obstructive sleep apnea syndrome.
MedLine Citation:
PMID:  18516636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The exact pathophysiology leading to pharyngeal collapse in obstructive sleep apnea syndrome (OSAS) remains incompletely understood. Prior research has shown that normal men have a longer pharyngeal airway than women, and it has been hypothesized that this difference may play a role in the gender-related differences in OSAS. In the current study, we sought to study the potential relationship between the length of the collapsible pharyngeal segment, the upper airway length (UAL), and the severity of OSAS. STUDY DESIGN: The hospital records were searched for all patients who had had polysomnography and also had had a computed tomography of the neck. A total of 24 such patients were identified who participated (15 men and nine women). MEASUREMENTS AND RESULTS: The UAL, the distance between the lower posterior part of the hard palate bone to the upper posterior part of the hyoid bone, was measured for all participants in the midsagittal plane. A correlation coefficient (Pearson r) of 0.406 was found between Respiratory Disturbance Index (RDI) and UAL (p = 0.049). When UAL was normalized to body height, a correlation coefficient (r) of 0.423 was found (p = 0.039). A gender-related difference in UAL was also found. Men with OSAS were found to have longer UAL even when normalized to body height (p = 0.003, unpaired t test) as compared with OSAS women. CONCLUSION: This study provides potential clinical relevance to prior studies in normal subjects, by demonstrating that men with OSAS have longer UAL than women with OSAS, independent of body size. In addition, the significant correlation between UAL and OSAS severity suggests that UAL may play a role in the pathophysiology of OSAS. These findings are consistent with our predictions from computational modeling studies.
Authors:
Yosef Segal; Atul Malhotra; Giora Pillar
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Publication Detail:
Type:  Journal Article     Date:  2008-05-31
Journal Detail:
Title:  Sleep & breathing = Schlaf & Atmung     Volume:  12     ISSN:  1520-9512     ISO Abbreviation:  Sleep Breath     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-09-30     Completed Date:  2009-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9804161     Medline TA:  Sleep Breath     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  311-6     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Haemek Medical Center and Technion--Israel Institute of Technology, Afula, Israel 18101. segalyg@bezeqint.net
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Cohort Studies
Female
Humans
Image Processing, Computer-Assisted*
Male
Middle Aged
Organ Size
Pharynx / physiopathology,  radiography*
Polysomnography
Reference Values
Risk Factors
Sex Factors
Sleep Apnea, Obstructive / physiopathology,  radiography*
Statistics as Topic
Tomography, X-Ray Computed*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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