| Upper esophageal sphincter and gastroesophageal junction pressure changes act to prevent gastroesophageal and esophagopharyngeal reflux during apneic episodes in patients with obstructive sleep apnea. | |
| | |
MedLine Citation:
|
PMID: 19914981 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Gastroesophageal reflux (GER) is thought to be induced by decreasing intraesophageal pressure during obstructive sleep apnea (OSA). However, pressure changes in the upper esophageal sphincter (UES) and gastroesophageal junction (GEJ) pressure during OSA events have not been measured. The aim of this study was to determine UES and GEJ pressure change during OSA and characterize the GER and esophagopharyngeal reflux (EPR) events during sleep. METHODS: We studied 15 controls, nine patients with GER disease (GERD) and without OSA, six patients with OSA and without GERD, and 11 patients with both OSA and GERD for 6 to 8 h postprandially during sleep. We concurrently recorded the following: (1) UES, GEJ, esophageal body (ESO), and gastric pressures by high-resolution manometry; (2) pharyngeal and esophageal reflux events by impedance and pH recordings; and (3) sleep stages and respiratory events using polysomnography. End-inspiration UES, GEJ, ESO, and gastric pressures over intervals of OSA were averaged in patients with OSA and compared with average values for randomly selected 10-s intervals during sleep in controls and patients with GERD. RESULTS: ESO pressures decreased during OSA events. However, end-inspiratory UES and GEJ pressures progressively increased during OSA, and at the end of OSA events were significantly higher than at the beginning (P < .01). The prevalence of GER and EPR events during sleep in patients with OSA and GERD did not differ from those in controls, patients with GERD and without OSA, and patients with OSA and without GERD. CONCLUSIONS: Despite a decrease in ESO pressure during OSA events, compensatory changes in UES and GEJ pressures prevent reflux. |
| | |
Authors:
|
Shiko Kuribayashi; Benson T Massey; Muhammad Hafeezullah; Lilani Perera; Syed Q Hussaini; Linda Tatro; Ronald J Darling; Rose Franco; Reza Shaker |
Publication Detail:
|
Type: Journal Article Date: 2009-11-13 |
Journal Detail:
|
Title: Chest Volume: 137 ISSN: 1931-3543 ISO Abbreviation: Chest Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-07 Completed Date: 2010-04-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
|
Languages: eng Pagination: 769-76 Citation Subset: AIM; IM |
Affiliation:
|
Division of Gastroenterology and Hepatology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Case-Control Studies Esophageal Sphincter, Upper / physiology* Esophageal pH Monitoring Esophagogastric Junction / physiology* Exhalation / physiology Female Gastroesophageal Reflux / physiopathology, prevention & control* Humans Inhalation / physiology Male Manometry Middle Aged Polysomnography Regurgitation, Gastric / physiopathology, prevention & control* Sleep Apnea, Obstructive / physiopathology* Young Adult |
| Comments/Corrections | |
Comment In:
|
Chest. 2010 Apr;137(4):747-8
[PMID:
20371523
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Semiqualitative Visual and Quantitative Morphometric Evaluations of Reduced Scan Time and Wide-Beam ...
Next Document: National networks of Healthy Cities in Europe.