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Updating the hippocampal representation of space: Place cell firing fields are controlled by a novel spatial stimulus.
MedLine Citation:
PMID:  20087890     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
To ask if the properties of spatial learning supported by the hippocampus are distinct from the properties of conditioning, we conducted a blocking-like experiment in which the measured variable was not a conditioned response but rather the ability of a novel visual stimulus to control the location of place cell firing fields after being briefly combined with a familiar, salient stimulus to form a compound stimulus. For most rats, we found that rotations of the novel stimulus on the wall of a cylindrical recording chamber produced equal rotations of firing fields, whether exposure to the compound stimulus lasted 10 min or 60 min. Thus, there was little indication that the blocking phenomenon (Kamin, 1969) acted to prevent the rapid inclusion of a new stimulus into a previously experienced cue constellation. This result is in agreement with the finding of Doeller and Burgess (2008) that blocking is seen for landmark stimuli inside an arena but not for boundary stimuli that circumscribe the arena. We conclude that the rules governing incidental spatial learning are different for the hippocampal representation of a rat's environment than for conditioning. © 2010 Wiley-Liss, Inc.
Authors:
Jeremy Barry; Robert Muller
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hippocampus     Volume:  21     ISSN:  1098-1063     ISO Abbreviation:  Hippocampus     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108167     Medline TA:  Hippocampus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  481-94     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley-Liss, Inc.
Affiliation:
School of Graduate Studies, Program in Neural and Behavioral Science, SUNY Downstate Medical Center, Brooklyn, New York. barjeremy@gmail.com.
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