Document Detail


Updates in reproduction coming from the endocannabinoid system.
MedLine Citation:
PMID:  24550985     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The endocannabinoid system (ECS) is an evolutionarily conserved master system deeply involved in the central and local control of reproductive functions in both sexes. The tone of these lipid mediators-deeply modulated by the activity of biosynthetic and hydrolyzing machineries-regulates reproductive functions from gonadotropin discharge and steroid biosynthesis to the formation of high quality gametes and successful pregnancy. This review provides an overview on ECS and reproduction and focuses on the insights in the regulation of endocannabinoid production by steroids, in the regulation of male reproductive activity, and in placentation and parturition. Taken all together, evidences emerge that the activity of the ECS is crucial for procreation and may represent a target for the therapeutic exploitation of infertility.
Authors:
Rosaria Meccariello; Natalia Battista; Heather B Bradshaw; Haibin Wang
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Publication Detail:
Type:  Journal Article; Review     Date:  2014-01-16
Journal Detail:
Title:  International journal of endocrinology     Volume:  2014     ISSN:  1687-8337     ISO Abbreviation:  Int J Endocrinol     Publication Date:  2014  
Date Detail:
Created Date:  2014-02-19     Completed Date:  2014-06-24     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101516376     Medline TA:  Int J Endocrinol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  412354     Citation Subset:  -    
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R21 DA032150/DA/NIDA NIH HHS

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