| Updates on bisphosphonates and potential pathobiology of bisphosphonate-induced jaw osteonecrosis. | |
| | |
MedLine Citation:
|
PMID: 18336375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Osteonecrosis of the jaws is a major complication associated with long-term use of bisphosphonates. While osteonecrosis can arise from other precipitating conditions, bisphosphonate-induced jaw osteonecrosis (BJON) is highly associated with long-term administration of pamidronate (Aredia) and zoledronic acid (Zometa), which are two intravenous bisphosphonate formulations. The underlying pathogenesis of BJON and its site-specific presentation still remain to be fully elucidated. This review will discuss clinically available bisphosphonates, current opinions, pathogenesis, and management guidelines for bisphosphonate-induced jaw osteonecrosis. |
| | |
Authors:
|
J Sarin; S S DeRossi; S O Akintoye |
Related Documents
:
|
19491045 - How to systematically evaluate immunogenicity of therapeutic proteins - regulatory cons... 2708935 - Pacemaker therapy for academic medicine. 19908675 - Medicines management in the theatre suite. 9306345 - Validation of different methods to calculate kt/v considering postdialysis rebound. 20219345 - Acute magnesium toxicity in an obstetric patient undergoing general anaesthesia for cae... 3904005 - Clinical brain imaging with isopropyl-iodoamphetamine and spect. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: Oral diseases Volume: 14 ISSN: 1601-0825 ISO Abbreviation: Oral Dis Publication Date: 2008 Apr |
Date Detail:
|
Created Date: 2008-03-13 Completed Date: 2008-06-16 Revised Date: 2010-08-20 |
Medline Journal Info:
|
Nlm Unique ID: 9508565 Medline TA: Oral Dis Country: Denmark |
Other Details:
|
Languages: eng Pagination: 277-85 Citation Subset: D |
Affiliation:
|
Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apoptosis Bone Density Conservation Agents / adverse effects*, pharmacokinetics Bone Remodeling / drug effects Diphosphonates / adverse effects*, pharmacokinetics Humans Jaw / blood supply, metabolism Jaw Diseases / chemically induced*, metabolism, prevention & control Neovascularization, Physiologic / drug effects Oral Hygiene Oral Surgical Procedures / contraindications Osteoclasts / drug effects Osteonecrosis / chemically induced*, metabolism, prevention & control RANK Ligand / antagonists & inhibitors |
| Grant Support | |
ID/Acronym/Agency:
|
1K08CA120875-01/CA/NCI NIH HHS; K08 CA120875-03/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Bone Density Conservation Agents; 0/Diphosphonates; 0/RANK Ligand |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical oral malodor measurement with a portable sulfide monitor.
Next Document: The revisit of 2004 tsunami in Thailand: characteristics of wounds.