Document Detail


Update on the use of cinacalcet in the management of primary hyperparathyroidism.
MedLine Citation:
PMID:  22104762     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cinacalcet is an allosteric modulator of the calcium sensing receptor acting to sensitize this receptor to the extracellular calcium. Cinacalcet has been shown to be effective in reducing or normalizing serum calcium levels in several groups of patients with primary hyperparathyroidism (PHPT), including patients with mild to moderate PHPT, intractable PHPT, and parathyroid carcinoma, and in PHPT as a part of multiple endocrine neoplasia type 1. Cinacalcet slightly reduces PTH levels and has no effects on bone mineral density. Cinacalcet at low doses is well tolerated, but side effects are more frequent and severe when relatively high doses are needed to control hypercalcemia. Cinacalcet may be of benefit in a wide spectrum of PHPT severity, offering a novel therapeutic option for the control of hypercalcemia in PHPT patients who are not able to undergo parathyroidectomy. To what extent the reduction of serum calcium particularly in patients with mild to moderate hypercalcemia, translates into a clinical benefit is currently unknown. Moreover, there are no data as to whether long-term treatment with cinacalcet can prevent the complications of PHPT. Finally, more data are needed on the long-term safety of cinacalcet, particularly at the renal level.
Authors:
C Marcocci; F Cetani
Publication Detail:
Type:  Journal Article; Review     Date:  2011-11-21
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  35     ISSN:  1720-8386     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-03-07     Completed Date:  2012-07-12     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  90-5     Citation Subset:  IM    
Affiliation:
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy. claudio.marcocci@med.unipi.it
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MeSH Terms
Descriptor/Qualifier:
Disease Management
Humans
Hyperparathyroidism, Primary / drug therapy*
Naphthalenes / therapeutic use*
Chemical
Reg. No./Substance:
0/Naphthalenes; UAZ6V7728S/cinacalcet

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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