Document Detail


Update on treatment of vesiculitis in bulls.
MedLine Citation:
PMID:  18514806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four experiments were done to determine: (1) the effectiveness of early detection and treatment of vesiculitis in bulls; (2) whether antibiotic treatment at recommended dosages will result in adequate vesicular gland tissue concentrations of antibiotics to prevent in vitro bacterial growth; (3) whether intraglandular injection of antibiotics can be a successful alternative to systemic antibiotic treatment; and (4) the effectiveness of tilmicosin versus tulathromycin for treatment of clinical vesiculitis. In Experiment 1, there was a high rate of spontaneous remission from vesiculitis detected at 9-12 mo of age. Furthermore, there was no advantage for early antibiotic treatment versus no treatment for bulls of this age. In Experiment 2, bacteria on agar plates were exposed to fluid extracted from vesicular gland biopsies after antibiotic treatment of normal, healthy bulls. Although inadequate concentrations of antibiotics were achieved to inhibit bacterial growth when recommended dosages of various antibiotics were administered, doubling the antibiotic dosage increased in vitro bacterial growth inhibition. In Experiment 3, relatively nonirritating antibiotics were injected directly into the glands of bulls with clinical vesiculitis, demonstrating that intraglandular injections of antibiotic could be used as a successful alternative to systemic antibiotic treatment. Experiment 4 was a clinical field trial to compare the efficacy of tilmicosin versus tulathromide at recommended dosages for the treatment of clinical vesiculitis. Although the results favored tulathromycin, both antibiotics resulted in clinical cures of vesiculitis.
Authors:
H Rovay; A D Barth; M Chirino-Trejo; M F Martínez
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-06-02
Journal Detail:
Title:  Theriogenology     Volume:  70     ISSN:  0093-691X     ISO Abbreviation:  Theriogenology     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-10-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421510     Medline TA:  Theriogenology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  495-503     Citation Subset:  IM    
Affiliation:
Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / administration & dosage,  therapeutic use
Bacteria / isolation & purification
Bacterial Infections / drug therapy,  microbiology,  veterinary
Cattle
Cattle Diseases / microbiology,  therapy*
Drug Administration Routes
Genital Diseases, Male / drug therapy,  microbiology,  veterinary*
Male
Seminal Vesicles
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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