| Update on the roles of distal airways in COPD. | |
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MedLine Citation:
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PMID: 21357888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review is the summary of a workshop on the role of distal airways in chronic obstructive pulmonary disease (COPD), which took place in 2009 in Vence, France. The evidence showing inflammation and remodelling in distal airways and the possible involvement of these in the pathobiology, physiology, clinical manifestations and natural history of COPD were examined. The usefulness and limitations of physiological tests and imaging techniques for assessing distal airways abnormalities were evaluated. Ex vivo studies in isolated lungs and invasive measurements of airway resistance in living individuals have revealed that distal airways represent the main site of airflow limitation in COPD. Structural changes in small conducting airways, including increased wall thickness and obstruction by muco-inflammatory exudates, and emphysema (resulting in premature airway closure), were important determinants of airflow limitation. Infiltration of small conducting airways by phagocytes (macrophages and neutrophils), dendritic cells and T and B lymphocytes increased with airflow limitation. Distal airways abnormalities were associated with patient-related outcomes (e.g. dyspnoea and reduced health-related quality of life) and with the natural history of the disease, as reflected by lung function decline and mortality. These data provide a clear rationale for targeting distal airways in COPD. |
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Authors:
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P-R Burgel; A Bourdin; P Chanez; F Chabot; A Chaouat; T Chinet; J de Blic; P Devillier; A Deschildre; A Didier; G Garcia; G Jebrak; F Laurent; H Morel; T Perez; C Pilette; N Roche; I Tillie-Leblond; S Verbanck; D Dusser |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: European respiratory review : an official journal of the European Respiratory Society Volume: 20 ISSN: 1600-0617 ISO Abbreviation: Eur Respir Rev Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-01 Completed Date: 2011-06-20 Revised Date: 2012-01-10 |
Medline Journal Info:
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Nlm Unique ID: 9111391 Medline TA: Eur Respir Rev Country: Denmark |
Other Details:
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Languages: eng Pagination: 7-22 Citation Subset: IM |
Affiliation:
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Service de Pneumologie, Hôpital Cochin, 27 rue du Faubourg St Jacques, Université Paris Descartes, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Airway Remodeling* Airway Resistance* Congresses as Topic Diagnostic Imaging Humans Lung / immunology, pathology, physiopathology* Predictive Value of Tests Pulmonary Disease, Chronic Obstructive / diagnosis, immunology, pathology, physiopathology* Respiratory Function Tests |
| Comments/Corrections | |
Erratum In:
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Eur Respir Rev. 2011 Jun;20(120):123 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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