Document Detail

Update on pharmacologic and nonpharmacologic therapies for smoking cessation.
MedLine Citation:
PMID:  18625823     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To review the evidence on the efficacy and safety of pharmacologic and nonpharmacologic therapies for smoking cessation. QUALITY OF EVIDENCE: MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews were searched for randomized controlled trials, meta-analyses, and systematic reviews (level I evidence) pertinent to pharmacologic and nonpharmacologic smoking cessation therapies. MAIN MESSAGE: Pharmacologic smoking cessation aids are recommended for all smokers trying to quit, unless contraindicated. A new pharmacologic smoking cessation aid, varenicline, is now available in Canada. Level I evidence at 1-year follow-up indicates that it is effective for smoking cessation. Adverse effects include nausea, insomnia, and abnormal dreaming. Nausea is mild or moderate and decreases over time. Varenicline is more effective than placebo or bupropion. Counseling also increases the likelihood of achieving cessation. CONCLUSION: Preliminary data indicate that varenicline is more effective than other available pharmacologic smoking cessation aids. Pharmacologic therapy should be combined with nonpharmacologic therapy.
Jason Schmelzle; Walter W Rosser; Richard Birtwhistle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Canadian family physician Médecin de famille canadien     Volume:  54     ISSN:  1715-5258     ISO Abbreviation:  Can Fam Physician     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-15     Completed Date:  2008-09-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0120300     Medline TA:  Can Fam Physician     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  994-9     Citation Subset:  IM    
Queen's University, Family Medicine, 220 Bagot St, PO Bag 8888, Kingston, ON K7L 5E9.
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MeSH Terms
Nicotinic Agonists / therapeutic use*
Smoking / drug therapy*,  prevention & control,  therapy
Smoking Cessation / methods*
Tobacco Use Disorder / drug therapy*
Reg. No./Substance:
0/Nicotinic Agonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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