| Update on pharmacologic and nonpharmacologic therapies for smoking cessation. | |
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MedLine Citation:
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PMID: 18625823 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To review the evidence on the efficacy and safety of pharmacologic and nonpharmacologic therapies for smoking cessation. QUALITY OF EVIDENCE: MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews were searched for randomized controlled trials, meta-analyses, and systematic reviews (level I evidence) pertinent to pharmacologic and nonpharmacologic smoking cessation therapies. MAIN MESSAGE: Pharmacologic smoking cessation aids are recommended for all smokers trying to quit, unless contraindicated. A new pharmacologic smoking cessation aid, varenicline, is now available in Canada. Level I evidence at 1-year follow-up indicates that it is effective for smoking cessation. Adverse effects include nausea, insomnia, and abnormal dreaming. Nausea is mild or moderate and decreases over time. Varenicline is more effective than placebo or bupropion. Counseling also increases the likelihood of achieving cessation. CONCLUSION: Preliminary data indicate that varenicline is more effective than other available pharmacologic smoking cessation aids. Pharmacologic therapy should be combined with nonpharmacologic therapy. |
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Authors:
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Jason Schmelzle; Walter W Rosser; Richard Birtwhistle |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Canadian family physician Médecin de famille canadien Volume: 54 ISSN: 1715-5258 ISO Abbreviation: Can Fam Physician Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-15 Completed Date: 2008-09-18 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0120300 Medline TA: Can Fam Physician Country: Canada |
Other Details:
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Languages: eng Pagination: 994-9 Citation Subset: IM |
Affiliation:
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Queen's University, Family Medicine, 220 Bagot St, PO Bag 8888, Kingston, ON K7L 5E9. jay.schmelzle@queensu.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Canada Humans Nicotinic Agonists / therapeutic use* Smoking / drug therapy*, prevention & control, therapy Smoking Cessation / methods* Tobacco Use Disorder / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Nicotinic Agonists |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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