Document Detail

Update on patient-triggered ventilation.
MedLine Citation:
PMID:  11570153     Owner:  NLM     Status:  MEDLINE    
Physiologic studies have demonstrated short-term benefits of triggered ventilation over conventional ventilation. The results of the randomized trials are disappointing. Meta-analysis has highlighted that the only significant difference in outcomes on PTV compared with conventional ventilation is a shorter duration of weaning. A few of the trials included infants with meconium aspiration syndrome and congenital pneumonia, but most infants randomized had RDS. In addition, a high proportion of the infants included in the meta-analysis were from two trials in which the SLE 2000 and airway pressure triggering system were mainly used. We cannot confidently conclude that in a population of infants with another respiratory disorder or even in those with RDS supported by an alternative triggering system, a different result might have been achieved. In addition, the benefits of PTV demonstrated in physiologic studies are largely related to achieving synchronized ventilation. In none of the randomized trials was any attempt made to determine if the infants were breathing synchronously with their ventilators. Before dismissing PTV for use in the management of infants with acute respiratory distress, an appropriately designed trial needs to take place. Essential, before any such trial, is identification of optimum method of PTV delivery, which may be disease specific.
A Greenough
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  28     ISSN:  0095-5108     ISO Abbreviation:  Clin Perinatol     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-25     Completed Date:  2002-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  533-46     Citation Subset:  IM    
Department of Child Health, Guy's King's and St Thomas' School of Medicine, King's College Hospital, London, United Kingdom.
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MeSH Terms
Infant, Newborn
Positive-Pressure Respiration
Respiration, Artificial / methods*
Respiratory Distress Syndrome, Newborn / therapy*
Ventilators, Mechanical

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