Document Detail

Update on the pathophysiology and management of uric acid renal stones.
MedLine Citation:
PMID:  20425021     Owner:  NLM     Status:  MEDLINE    
Idiopathic uric acid nephrolithiasis appears to be increasing in prevalence. While it has long been known that low urine pH is associated with uric acid stones, only recently has the pathophysiological basis for this disease emerged. Excessively acidic urine is the decisive risk for uric acid lithogenesis, and patients with diabetes and the metabolic syndrome often hold the company of low urine pH. While association does not imply causation, interesting insights have been made regarding insulin's influence on acid-base physiology. We review recent evidence from both the molecular and clinical realms to underline the importance of [H+] in the development and treatment of uric acid nephrolithiasis.
Jon-Emile S Kenny; David S Goldfarb
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current rheumatology reports     Volume:  12     ISSN:  1534-6307     ISO Abbreviation:  Curr Rheumatol Rep     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888970     Medline TA:  Curr Rheumatol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-9     Citation Subset:  IM    
Department of Medicine, NYU Langone Medical Center, New York, NY, USA.
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MeSH Terms
Alkalies / therapeutic use
Diet Therapy
Hydrogen-Ion Concentration
Hyperuricemia / diet therapy,  drug therapy,  prevention & control*
Kidney Calculi / metabolism,  physiopathology*,  therapy*
Potassium Citrate / therapeutic use
Uric Acid / metabolism*
Reg. No./Substance:
0/Alkalies; 6100-05-6/Potassium Citrate; 69-93-2/Uric Acid

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