| Update on the pathophysiology and management of uric acid renal stones. | |
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MedLine Citation:
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PMID: 20425021 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Idiopathic uric acid nephrolithiasis appears to be increasing in prevalence. While it has long been known that low urine pH is associated with uric acid stones, only recently has the pathophysiological basis for this disease emerged. Excessively acidic urine is the decisive risk for uric acid lithogenesis, and patients with diabetes and the metabolic syndrome often hold the company of low urine pH. While association does not imply causation, interesting insights have been made regarding insulin's influence on acid-base physiology. We review recent evidence from both the molecular and clinical realms to underline the importance of [H+] in the development and treatment of uric acid nephrolithiasis. |
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Authors:
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Jon-Emile S Kenny; David S Goldfarb |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Current rheumatology reports Volume: 12 ISSN: 1534-6307 ISO Abbreviation: Curr Rheumatol Rep Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888970 Medline TA: Curr Rheumatol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 125-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, NYU Langone Medical Center, New York, NY, USA. Jon-Emile.Kenny@nyumc.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkalies
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therapeutic use Diet Therapy Humans Hydrogen-Ion Concentration Hyperuricemia / diet therapy, drug therapy, prevention & control* Kidney Calculi / metabolism, physiopathology*, therapy* Potassium Citrate / therapeutic use Uric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Alkalies; 6100-05-6/Potassium Citrate; 69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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