| Update of pathogen reduction technology for therapeutic plasma. | |
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MedLine Citation:
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PMID: 20395932 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the developed world, blood products are tested for the presence of some of pathogens prior to administration. There exists a small, but definite risk of transmission of infectious agents. The risk of transmission of viral infection is due to the "window period": the period of time between the infection of a donor and the development of detectable level of antibodies. Nucleic acid amplification testing (NAT) was introduced for HIV and HCV in the United States in 1998 and has shortened the window period and further decreased the incidence of pathogens in transfused units of blood products. The development of increasingly sensitive laboratory screening methods and restrictive donor criteria has greatly decreased the risk of transmission of many pathogens through blood transfusion; however, transfusion is still not risk free. Blood is currently not tested for many potentially dangerous known pathogens. The emergence of new agents such as West Nile Virus (WNV) demonstrates that potential threats to the blood supply continue to emerge world wide. The testing and donor rejection methods currently used to screen the blood supply may not offer complete protection against all of these emerging infectious agents. This overview aims to provide an update on the continual improvements in blood component safety in particular using methods that target pathogen's nucleic acid. |
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Authors:
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P Chakrabarty; S Rudra; M M Hoque |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Mymensingh medical journal : MMJ Volume: 19 ISSN: 1022-4742 ISO Abbreviation: Mymensingh Med J Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-16 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9601799 Medline TA: Mymensingh Med J Country: Bangladesh |
Other Details:
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Languages: eng Pagination: 308-11 Citation Subset: IM |
Affiliation:
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Department of Blood Transfusion, Mymensingh Medical College, Mymensingh, Bangladesh. drpcbabnle@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acridines
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pharmacology Blood / microbiology* Blood Component Transfusion / adverse effects* Blood Preservation / methods Blood-Borne Pathogens* Communicable Disease Control / methods* Detergents / pharmacology Disinfection / methods* Ficusin / pharmacology Filtration / methods Humans Methylene Blue / pharmacology Nitrogen Mustard Compounds / pharmacology Polyamines / pharmacology Radiation-Sensitizing Agents / pharmacology Riboflavin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/(N,N-bis(2-chloroethyl))-2-aminoethyl-3-((acridin-9-yl)amino)propionate; 0/Acridines; 0/Detergents; 0/Nitrogen Mustard Compounds; 0/PEN 110; 0/Polyamines; 0/Radiation-Sensitizing Agents; 61-73-4/Methylene Blue; 66-97-7/Ficusin; 83-88-5/Riboflavin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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