Document Detail

Update on pancreatic polypeptide as a specific marker for endocrine tumours of the pancreas and gut.
MedLine Citation:
PMID:  6270987     Owner:  NLM     Status:  MEDLINE    
Serum levels of pancreatic polypeptide (PP) were determined in 31 patients with endocrine tumours, localized in the pancreas (n = 16), small intestine (n = 13) and respiratory tract (n = 2). Two further patients with laxative abuse were investigated. Elevated serum levels in the peripheral circulation were noted in 56% of the patients with pancreatic tumours, in 60% of those with gut or bronchial tumours and in both patients with laxative abuse. Our study suggests that the elevated PP concentrations found in connection with endocrine gastrointestinal tumours originate from non-tumour pancreatic PP cells and only occasionally from the tumour. PP is a valuable tumour marker for endocrine gastrointestinal tumours, although it is not specific for pancreatic tumours. Certain inflammatory diseases, renal function and consumption of laxatives must be considered when evaluating elevated PP levels. Serum PP seems to be of limited value for evaluating the response to cytotoxic therapy.
K Oberg; L Grimelius; G Lundqvist; L E Lörelius
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  210     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1981  
Date Detail:
Created Date:  1981-12-22     Completed Date:  1981-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  145-52     Citation Subset:  IM    
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MeSH Terms
Bronchial Neoplasms / blood*
Carcinoid Tumor / blood
Cathartics / adverse effects
Duodenal Neoplasms / blood
Ileal Neoplasms / blood
Intestinal Neoplasms / blood*
Middle Aged
Pancreatic Neoplasms / blood*
Pancreatic Polypeptide / blood*
Streptozocin / therapeutic use
Substance-Related Disorders
Vipoma / blood
Zollinger-Ellison Syndrome / blood
Reg. No./Substance:
0/Cathartics; 18883-66-4/Streptozocin; 59763-91-6/Pancreatic Polypeptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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