Document Detail


Update on nutritional supplementation with branched-chain amino acids.
MedLine Citation:
PMID:  15586005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Branched-chain amino acids (BCAAs) have a peculiar role in whole-body nitrogen metabolism. BCAAs are not only a substrate for protein synthesis, but also modulate several components of the synthetic machinery and help to conserve muscle mass; accordingly, several conditions, characterized by protein loss and catabolic status, are likely to benefit from amino acid administration. In addition, the competitive action of BCAAs on amino acid transport across the blood-brain barrier may ultimately alter the synthesis of brain neurotransmitters, involved in neurological diseases. RECENT FINDINGS: Both putative actions of BCAAs have been tested in controlled clinical studies in the last few years. The beneficial effects on nutrition were reported to improve muscle performance, reduce protein loss during bed-rest, favor weight loss in obesity, reduce catabolism in trauma patients and improve clinical outcomes in patients with advanced cirrhosis. In this last area, the effects on nutrition might be coupled with the effects on hepatic encephalopathy mediated by improved neurotransmission, successfully tested in mania, tardive dyskinesia and spinocerebellar degeneration. SUMMARY: After 30 years of investigation with BCAAs, new studies each year provide further evidence supporting their beneficial effect in a variety of diseases. There is a need for long-term, randomized clinical studies, both in the prevention and in the treatment of various pathological conditions.
Authors:
Giampaolo Bianchi; Rebecca Marzocchi; Federica Agostini; Giulio Marchesini
Related Documents :
16662855 - Ammonia assimilation in the roots of nitrate- and ammonia-grown hordeum vulgare (cv gol...
22712045 - Association between serum uric acid level and metabolic syndrome.
17986345 - Are we getting enough sulfur in our diet?
12945705 - Nitration of moderately deactivated arenes with nitrogen dioxide and molecular oxygen u...
17025055 - Fabrication and electrocatalysis of self-assembly directed gold nanoparticles anchored ...
14703345 - Highly substituted pyrrolidinones and pyridones by 4-cr/2-cr sequence.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  8     ISSN:  1363-1950     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-08     Completed Date:  2005-04-21     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  83-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acids, Branched-Chain / administration & dosage*,  therapeutic use
Brain / metabolism*
Dietary Supplements
Gluconeogenesis
Humans
Liver Diseases / therapy
Muscle, Skeletal / metabolism*
Neurotransmitter Agents / metabolism
Obesity / therapy
Chemical
Reg. No./Substance:
0/Amino Acids, Branched-Chain; 0/Neurotransmitter Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Microdialysis to investigate tissue amino acid kinetics.
Next Document:  Optimizing protein intake in aging.