Document Detail

Update on nutritional supplementation with branched-chain amino acids.
MedLine Citation:
PMID:  15586005     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Branched-chain amino acids (BCAAs) have a peculiar role in whole-body nitrogen metabolism. BCAAs are not only a substrate for protein synthesis, but also modulate several components of the synthetic machinery and help to conserve muscle mass; accordingly, several conditions, characterized by protein loss and catabolic status, are likely to benefit from amino acid administration. In addition, the competitive action of BCAAs on amino acid transport across the blood-brain barrier may ultimately alter the synthesis of brain neurotransmitters, involved in neurological diseases. RECENT FINDINGS: Both putative actions of BCAAs have been tested in controlled clinical studies in the last few years. The beneficial effects on nutrition were reported to improve muscle performance, reduce protein loss during bed-rest, favor weight loss in obesity, reduce catabolism in trauma patients and improve clinical outcomes in patients with advanced cirrhosis. In this last area, the effects on nutrition might be coupled with the effects on hepatic encephalopathy mediated by improved neurotransmission, successfully tested in mania, tardive dyskinesia and spinocerebellar degeneration. SUMMARY: After 30 years of investigation with BCAAs, new studies each year provide further evidence supporting their beneficial effect in a variety of diseases. There is a need for long-term, randomized clinical studies, both in the prevention and in the treatment of various pathological conditions.
Giampaolo Bianchi; Rebecca Marzocchi; Federica Agostini; Giulio Marchesini
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  8     ISSN:  1363-1950     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-08     Completed Date:  2005-04-21     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  83-7     Citation Subset:  IM    
Department of Internal Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy.
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MeSH Terms
Amino Acids, Branched-Chain / administration & dosage*,  therapeutic use
Brain / metabolism*
Dietary Supplements
Liver Diseases / therapy
Muscle, Skeletal / metabolism*
Neurotransmitter Agents / metabolism
Obesity / therapy
Reg. No./Substance:
0/Amino Acids, Branched-Chain; 0/Neurotransmitter Agents

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