| Update on nutritional supplementation with branched-chain amino acids. | |
| | |
MedLine Citation:
|
PMID: 15586005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE OF REVIEW: Branched-chain amino acids (BCAAs) have a peculiar role in whole-body nitrogen metabolism. BCAAs are not only a substrate for protein synthesis, but also modulate several components of the synthetic machinery and help to conserve muscle mass; accordingly, several conditions, characterized by protein loss and catabolic status, are likely to benefit from amino acid administration. In addition, the competitive action of BCAAs on amino acid transport across the blood-brain barrier may ultimately alter the synthesis of brain neurotransmitters, involved in neurological diseases. RECENT FINDINGS: Both putative actions of BCAAs have been tested in controlled clinical studies in the last few years. The beneficial effects on nutrition were reported to improve muscle performance, reduce protein loss during bed-rest, favor weight loss in obesity, reduce catabolism in trauma patients and improve clinical outcomes in patients with advanced cirrhosis. In this last area, the effects on nutrition might be coupled with the effects on hepatic encephalopathy mediated by improved neurotransmission, successfully tested in mania, tardive dyskinesia and spinocerebellar degeneration. SUMMARY: After 30 years of investigation with BCAAs, new studies each year provide further evidence supporting their beneficial effect in a variety of diseases. There is a need for long-term, randomized clinical studies, both in the prevention and in the treatment of various pathological conditions. |
| | |
Authors:
|
Giampaolo Bianchi; Rebecca Marzocchi; Federica Agostini; Giulio Marchesini |
Related Documents
:
|
16662855 - Ammonia assimilation in the roots of nitrate- and ammonia-grown hordeum vulgare (cv gol... 22712045 - Association between serum uric acid level and metabolic syndrome. 17986345 - Are we getting enough sulfur in our diet? 12945705 - Nitration of moderately deactivated arenes with nitrogen dioxide and molecular oxygen u... 17025055 - Fabrication and electrocatalysis of self-assembly directed gold nanoparticles anchored ... 14703345 - Highly substituted pyrrolidinones and pyridones by 4-cr/2-cr sequence. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current opinion in clinical nutrition and metabolic care Volume: 8 ISSN: 1363-1950 ISO Abbreviation: Curr Opin Clin Nutr Metab Care Publication Date: 2005 Jan |
Date Detail:
|
Created Date: 2004-12-08 Completed Date: 2005-04-21 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9804399 Medline TA: Curr Opin Clin Nutr Metab Care Country: England |
Other Details:
|
Languages: eng Pagination: 83-7 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acids, Branched-Chain
/
administration & dosage*,
therapeutic use Brain / metabolism* Dietary Supplements Gluconeogenesis Humans Liver Diseases / therapy Muscle, Skeletal / metabolism* Neurotransmitter Agents / metabolism Obesity / therapy |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids, Branched-Chain; 0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Microdialysis to investigate tissue amino acid kinetics.
Next Document: Optimizing protein intake in aging.